Table 3 BEAMing vs. EMR-qPCR crosstabulation for EGFR exon19, 20 and 21.

From: Comparative analysis of EGFR mutations in circulating tumor DNA and primary tumor tissues from lung cancer patients using BEAMing PCR

  

Negative

Positive

Total

P value1

Kappa

P value2

BEAMing-Exon 19

       

EMR-qPCR Exon 19

Negative

65 (74.7%)

1 (1.1%)

66 (75.9%)

1

0.969

< 0.001

Positive

0 (0%)

21 (24.1%)

21 (4.1%)

Total

65 (74.7%)

22 (25.3%)

87 (100%)

BEAMing-Exon 20

    

EMR-qPCR Exon 20

Negative

94 (98.9%)

0 (0%)

94 (98.9%)

1

1

< 0.001

Positive

1 (1.1%)

0 (0%)

1 (1.1%)

Total

95 (100%)

0 (0%)

95 (100%)

BEAMing-Exon 21

   

EMR-qPCR Exon 21

Negative

75 (86.2%)

1 (1.1%)

76 (87.4%)

0.625

0.774

< 0.001

Positive

3 (3.4%)

8 (9.2%)

11 (12.6%)

Total

78 (89.7%)

9 (10.3%)

87 (100%)

  1. 1P value calculated using McNemar test
  2. 2P value calculated for Kappa statistics