Fig. 12 | Scientific Reports

Fig. 12

From: Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma

Fig. 12

Screening for potential therapeutic drugs targeting patients with high PTGES3 levels. (A-B) Calculation of the half-maximal inhibitory concentration (IC50) values for PR-deficient cells and presentation of the top 10 drugs with significant negative and positive correlations with PTGES3. (C-E) Distribution differences of three drugs in the high PTGES3 group and low PTGES3 group. (F-H) Evaluation and analysis of the docking results of the top three drugs with significant negative correlations with PTGES3 using the PLIP system (https://plip-tool.biotec.tu-dresden.de/plip-web/plip/index), visualization with LIGPLOT software version 4.5.3; and generation of molecular docking diagrams using PyMOL. * p < 0.05 **p < 0.01 ***p < 0.001; NS indicates no statistical.

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