Table 2 Correlations between TIMP1 histoscore in tumors (tumor cells and stromal cells), TIMP1 serum levels, histological features, and systemic inflammation markers.

From: Associations of serum and tissue TIMP1 with host response and survival in colorectal cancer

Variable

TIMP1 histoscore in tumors

TIMP1 serum

N

TIMP1 tumor cells

TIMP1 stromal cells

N

 

Unadjusted

Adjusted

Unadjusted

Adjusted

Unadjusted

Adjusted

Pearson r

p value

Beta

p value

Pearson r

p value

Beta

p value

Pearson r

p value

Beta

p value

TIMP1 histoscore tumor cells

757

1

–

–

–

0.76

< 0.001

0.74

< 0.001

591

0.016

0.69

− 0.021

0.62

TIMP1 histoscore stromal cells

757

0.76

< 0.001

0.74

< 0.001

1

–

–

–

591

0.016

0.69

− 0.014

0.75

CD3 + T cell overall density

756

0.032

0.39

− 0.010

0.79

0.14

< 0.001

0.085

0.026

594

− 0.061

0.14

− 0.051

0.25

CD3 + T cell density (CT, epithelial)

755

− 0.070

0.054

− 0.14

< 0.001

0.021

0.56

− 0.061

0.11

594

− 0.119

0.004

− 0.13

0.004

CD3 + T cell density (CT, stromal)

755

− 0.14

< 0.001

− 0.16

< 0.001

− 0.054

0.14

− 0.082

0.029

594

− 0.080

0.051

− 0.051

0.24

CD3 + T cell density (IM, epithelial)

749

0.014

0.70

− 0.023

0.55

0.12

0.001

0.066

0.079

589

− 0.089

0.031

− 0.090

0.40

CD3 + T cell density (IM, stromal)

749

0.00

0.99

− 0.022

0.56

0.14

< 0.001

0.11

0.005

589

− 0.056

0.17

− 0.041

0.34

CD8 + T cell overall density

756

0.060

0.10

− 0.011

0.78

0.20

< 0.001

0.13

< 0.001

594

− 0.015

0.71

− 0.031

0.48

CD8 + T cell density (CT, epithelial)

755

− 0.030

0.40

− 0.10

0.008

0.079

0.029

− 0.009

0.81

594

− 0.046

0.26

− 0.054

0.23

CD8 + T cell density (CT, stromal)

755

− 0.044

0.23

− 0.10

0.006

0.083

0.023

0.012

0.76

594

− 0.008

0.86

− 0.019

0.66

CD8 + T cell density (IM, epithelial)

751

0.010

0.78

− 0.052

0.18

0.10

< 0.001

0.021

0.58

590

− 0.041

0.32

− 0.047

0.29

CD8 + T cell density (IM, stromal)

751

0.033

0.36

− 0.013

0.73

0.18

< 0.001

0.13

< 0.001

590

− 0.011

0.80

− 0.012

0.79

Tumor necrosis percentage

757

− 0.16

< 0.001

− 0.14

< 0.001

− 0.069

0.057

− 0.016

0.68

606

0.10

0.012

0.091

0.034

Blood neutrophil count

712

0.014

0.71

− 0.016

0.67

− 0.051

0.18

− 0.082

0.026

595

0.25

< 0.001

0.22

< 0.001

Blood lymphocyte count

712

0.002

0.95

− 0.008

0.82

− 0.079

0.035

− 0.085

0.018

595

− 0.059

0.15

− 0.052

0.20

NLR

712

0.014

0.72

− 0.002

0.97

0.023

0.55

0.005

0.89

595

0.23

< 0.001

0.20

< 0.001

Serum CRP

704

0.087

0.021

0.049

0.20

0.070

0.065

0.043

0.26

598

0.43

< 0.001

0.41

< 0.001

Serum albumin

747

− 0.15

< 0.001

− 0.12

< 0.001

− 0.19

< 0.001

− 0.17

< 0.001

597

− 0.23

< 0.001

− 0.19

< 0.001

Serum IL6

588

0.041

0.32

0.006

0.88

0.031

0.46

0.005

0.91

603

0.44

< 0.001

0.41

< 0.001

  1. The adjusted beta coefficients and P values were calculated with linear regression models that included age (< 65, ≥ 65), sex (male, female), tumor localization (colon, rectum), T class (T1–T2, T3–T4), N class (N0, N1–N2), M class (M0, M1), BRAF status (wild-type, mutant), MMR status (proficient, deficient), and tumor grade (low, high). Continuous variables with positive skewness were logarithmically transformed.
  2. CT tumor center, CRP C-reactive protein, IL interleukin, IM invasive margin, NLR neutrophil-to-lymphocyte ratio.
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