Table 3 Univariable and multivariable Cox regression models for cancer-specific survival and overall survival according to TIMP1 histoscore and TIMP1 serum levels.

From: Associations of serum and tissue TIMP1 with host response and survival in colorectal cancer

 

No. of cases

Colorectal cancer-specific survival

Overall survival

No. of events

Univariable

HR (95% CI)

Multivariable

HR (95% CI)

No. of events

Univariable

HR (95% CI)

Multivariable

HR (95% CI)

TIMP1 histoscore in tumor cells

 ≤ 76.7

227

50

1 (referent)

1 (referent)

85

1 (referent)

1 (referent)

 > 76.7

525

83

0.79 (0.56–1.13)

1.08 (0.74–1.57)

153

0.92 (0.70–1.20)

1.13 (0.85 − 0.15)

 P

  

0.20

0.68

 

0.52

0.39

TIMP1 histoscore in stromal cells

 ≤ 54.2

193

55

1 (referent)

1 (referent)

87

1 (referent)

1 (referent)

 > 54.2

559

78

0.53 (0.37–0.75)

0.91 (0.62–1.35)

151

0.69 (0.53–0.90)

0.99 (0.74–1.34)

 P

  

< 0.001

0.66

 

0.006

0.97

Serum TIMP1

 ≤ 399.7 ng/ml

494

67

1 (referent)

1 (referent)

115

1 (referent)

1 (referent)

 > 399.7 ng/ml

108

23

2.05 (1.27–3.30)

1.29 (0.77–2.16)

49

2.66 (1.90–3.73)

1.85 (1.30–2.65)

 P

  

0.003

0.34

 

< 0.001

< 0.001

  1. Multivariable Cox proportional hazards regression models were adjusted for sex, age (< 65, 65–75, > 75), year of operation (2006–2010, 2011–2015, 2016–2020), tumor location (proximal colon, distal colon, rectum), disease stage (I–II, III, IV), tumor grade (well/moderately differentiated, poorly differentiated), lymphovascular invasion (negative, positive), mismatch repair (MMR) status (proficient, deficient), BRAF status (wild-type, mutant). The missing data in the TIMP1 serum model (n = 6 for BRAF status) were included in the majority category (BRAF wild-type) to limit the degrees of freedom.
  2. CI confidence interval, HR hazard ratio.
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