Fig. 1
Effect of PAS on cell cytotoxicity. (A) Schematic overview of PAS exposure of long and short distance. (B) Effect of short/long distance PAS on formed reactive species in PBS. (C) Effect of short/long distance PAS on cellular cytotoxicity. (D) Effect of short-term storage time on PAS stability. (E) Effect of long-term storage of PAS on its stability. ***p < 0001, nd, not-detectable. (F) Comparison of PAS vs H2O2 on cellular cytotoxicity. ***p < 0001 (G) IC50 after PAS-exposure to different (precursor) HNSCC cell lines, datapoints show an average of triplicate measurements (H) Effect of 20% PAS on the mitochondrial membrane potential. (I) Effect of PAS on intracellular ROS formation. All datapoints show an average of 3 independent experiments, significance is shown across all timepoints of the graph compared to the 0 h timepoint.
