Table 1 Two-by-two contingency table for disproportional analysis.

From: Pharmacovigilance study of the association between progestogen and depression based on the FDA adverse event reporting System (FAERS)

 

Depression

All other adverse drug reactions

Total

Progestogen

a

b

a + b

All other drugs

c

d

c + d

Total

a + c

b + d

N = a + b + c + d

  1. ROR=(a/c)/(b/d),95%CI=eln(ROR)±1.96(1/a+1/b +1/c+1/d)^0.5(criteria: 95% CI > 1, a＞3);
  2. PRR = (a / [a + c]) / (b / [b + d]);95% CI=eln(PRR)±1.96(1/a-1/a+b +1/c-1/c+d)^0.5(criteria: 95% CI > 1, a＞3);
  3. IC =log 2a*(a + b + c + d)/([a + c][a + b]); IC 025=eln(IC)-1.96(1/a+1/b+1/c+1/d)^0.5(criteria : IC 025 > 0);
  4. EBGM = a*(a + b + c + d)/([a + c][a + b]).EBGM 05=eln(EBGM)-1.64(1/a+1/b +1/c+1/d)^0.5(criteria : EBGM 05 > 2).
  5. IC 025: the lower limit of the 95% two-sided CI of the IC
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