Table 3 Association of progestogen with depression.

From: Pharmacovigilance study of the association between progestogen and depression based on the FDA adverse event reporting System (FAERS)

Drug

Cases Reports

ROR (95% two-side CI)

PRR (95% two-side CI)

IC (IC 025)

EBGM (EBGM 05)

Levonorgestrel

4812

2.55(2.48–2.63)*

2.54(2.46–2.61)*

1.31(1.27)*

2.48(2.41)*

Etonogestrel

1082

1.65(1.56–1.75)*

1.65(1.55–1.75)*

0.72(0.63)*

1.64(1.55)

Medroxyprogesterone

461

2.27(2.07–2.49)*

2.26(2.06–2.48)*

1.17(1.03)*

2.26(2.06)*

Hydroxyprogesterone

107

0.85(0.70–1.03)

0.85(0.71–1.03)

−0.23(−0.51)

0.85(0.71)

Progesterone

29

0.95(0.66–1.37)

0.95(0.66–1.37)

−0.07(−0.60)

0.95(0.66)

Desogestrel

10

2.13(1.14–3.96)*

2.12(1.14–3.92)*

1.08(0.07)*

2.12(1.13)

Megestrol

1

0.16(0.02–1.17)

0.16(0.02–1.17)

−2.60(−3.86)

0.16(0.02)

  1. ROR: reporting odds ratio; CI: confidence interval; PRR: proportional reporting ratio; IC: information component; EBGM: empirical Bayesian geometric mean; IC 025: the lower limit of the 95% two-sided CI of the IC; EBGM 05:the lower limit of the 90% one-sided CI of the EBGM. *progestogen are associated with depression.
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