Fig. 3

(a–e) Breast lesion in a 39-year-old female. (a) Conventional ultrasound showing a solid hypoechoic irregular mass with angular margins measuring approximately 21 mm × 21 mm × 9 mm. The lesion has a parallel orientation. No calcifications and no change in posterior acoustic features were noted. The lesion was categorized as BI-RADS 4 A. (b) SWE_Max: 26.2 kPa. (c) CEUS demonstrates no enlargement of the lesion post-contrast administration. (d) PI: 13.88, AUC: 0.996. When incorporated into the nomogram model, the risk of malignancy was less than 10%. (e) Histopathological examination (HE) staining; (original magnification 40×) confirmed the presence of fibroadenoma with adenosis in the breast tissue. (f–j) Breast lesion in a 47-year-old female. (f) Conventional ultrasound showing a solid hypoechoic mass irregular mass with angular margins measuring approximately 18 × 15 × 9 mm. The lesion has a parallel orientation, no calcifications, and no change in the posterior acoustic features. The lesion was categorized as BI-RADS 4 A. (g) SWE_Max: 61.7 kPa. (h) CEUS shows enhancement. (i) PI: 27.88, AUC: 1901.76. When incorporated into the nomogram model, the risk of malignancy of the breast lesion was more than 90%. (j) Histopathological examination (original magnification 40×) confirmed intraductal carcinoma.