Table 1 Joint/Conditional analysis findings: jointly and marginally significant features per locus.

From: Integrative bioinformatics approach identifies novel drug targets for hyperaldosteronism, with a focus on SHMT1 as a promising therapeutic candidate

Location

Jointly sign. Features

(SNP-weight set)

Marginally sign. Features

(SNP-weight set)

BEST.

GWAS.P

BEST.

TWAS.P

Variance explained

chr1:3131235–4,370,489

CEP104(GTEx.Adrenal_Gland)

CEP104(GTEx.Whole_Blood)

0.000294603

0.000976

82.60%

chr1:51684980–53,666,965

RP4-657D16.3(GTEx.Whole_Blood)

NRD1(GTEx.Whole_Blood),

GPX7(GTEx.Whole_Blood)

0.000400127

0.0014

67.30%

chr2:23555150–24,985,719

UBXN2A(GTEx.Whole_Blood)

FAM228B(GTEx.Adrenal_Gland), C2orf44(GTEx.Whole_Blood), TP53I3(GTEx.Whole_Blood)

0.000207259

0.000233

82%

chr3:194789032–196,054,860

SDHAP2(GTEx.Whole_Blood)

LINC00969(GTEx.Adrenal_Gland), LINC00969(GTEx.Whole_Blood)

0.005780136

0.00319

61.90%

chr7:74489889–75,963,169

HIP1(GTEx.Whole_Blood)

PMS2P2(GTEx.Adrenal_Gland)

0.000431547

0.00157

58.70%

chr8:145031265–146,251,362

TONSL(GTEx.Adrenal_Gland)

CPSF1(GTEx.Adrenal_Gland), CPSF1(GTEx.Whole_Blood), VPS28(GTEx.Whole_Blood)

0.000808116

0.000831

90.30%

chr10:42517060–43,731,521

ZNF33B(GTEx.Whole_Blood)

ZNF33B(GTEx.Adrenal_Gland)

6.07187E-05

0.000251

82.10%

chr10:76768023–78,917,488

C10orf11(GTEx.Adrenal_Gland)

-

0.001114122

0.00205

63.40%

chr11:116452887–117,671,091

SIDT2(GTEx.Whole_Blood)

TAGLN(GTEx.Whole_Blood)

0.000272638

0.0075

51.70%

chr15:67097860–68,425,265

IQCH-AS1(GTEx.Adrenal_Gland)

IQCH-AS1(GTEx.Whole_Blood), RP11-502I4.3(GTEx.Whole_Blood)

0.000330678

0.000769

80.30%

chr16:89146523–90,172,696

SPATA33(GTEx.Whole_Blood)

-

0.000603581

0.00383

69.10%

chr17:17634281–18,325,085

SHMT1(GTEx.Adrenal_Gland)

SHMT1(GTEx.Whole_Blood)

0.001632705

0.000199

100%

chr17:18512255–18,923,818

CCDC144B(GTEx.Whole_Blood)

CCDC144B(GTEx.Adrenal_Gland), CTD-2303H24.2(GTEx.Whole_Blood)

0.001237902

0.003452

8.40%

chr18:33093406–34,355,579

SLC39A6(GTEx.Whole_Blood)

ELP2(GTEx.Whole_Blood)

0.002140588

0.008923

35.30%

chr18:47806957–49,072,801

ME2(GTEx.Whole_Blood)

-

6.60733E-05

0.000301

16.80%

chr19:21306913–22,542,439

ZNF100(GTEx.Adrenal_Gland)

ZNF100(GTEx.Whole_Blood)

0.000176835

0.000226

62.40%

chr21:46095015–47,530,602

POFUT2(GTEx.Whole_Blood)

COL18A1(GTEx.Whole_Blood)

0.000698926

0.014

25%

chr22:20732809–21,811,991

PI4KA(GTEx.Adrenal_Gland)

AIFM3(GTEx.Whole_Blood)

0.001870873

0.00241

25.70%

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