Fig. 5

Lipidomic results K-562 cells. (A) Heatmaps depicting glycerophospholipids changes associated with CBD treatment observed in LC–MS (+). Only lipids with q-value < 0.05 and VIP > 1 are shown. (B) Heatmaps depicting the rest of lipids changes associated with CBD treatment observed in LC–MS (+). Only lipids with q-value < 0.05 and VIP > 1 are shown. (C) Heatmaps depicting metabolic changes associated with CBD treatment observed in LC–MS (−). Only lipids with q-value < 0.05 and VIP > 1 are shown. (D) Lipid network between the two conditions with node size scaled by log₁₀ of the q-value in the comparison with Mann–Whitney U test between CBD treated vs control. The color indicates fold change between the two conditions. The blue color indicates lower levels of lipids in the CBD-treated condition compared to the control and red higher levels in CBD-treated samples. Edges are colored by reaction types. The blue edge means fatty acids deleted, the orange edge means fatty acids modified, the green edge means head groups deleted, red edge means head groups modified. Network generated with LINEX2 software⁵⁹.