Table 3 Types of drug-related problems and causes among ambulatory thyroid disease patients who have a follow-up in selected hospitals of Northwest Ethiopia, from July 01-Sept 30, 2022, (n = 351).
From: Drug related problems and associated factors among thyroid disorder patients in Northwest Ethiopia
Type of DRPs | Related causes | Frequency N (%) |
---|---|---|
Unnecessary drug therapy | No clear indication of drug use | 7 (70.00) |
Drug therapy is being taken to treat an avoidable adverse reaction associated with another medication | 3 (30.00) | |
Need additional drug therapy | A medical condition requires the initiation of drugs | 6 (50.00) |
Prophylactic/preventive drug therapy | 2 (16.67) | |
Drugs not taken /administered at all | 4 (33.33) | |
Ineffective Drug | Not most effective for the indication being treated | 11 (39.29) |
prescribed effective drug not available | 17 (60.71) | |
Dose too low | The dose is too low to produce the desired response | 20 (95.24) |
Drug underused/ under administered | 1 (4.76) | |
Dose too high | The duration of the drug therapy is too long | 24 (88.89) |
Drug overused/over administered | 3 (11.11) | |
Adverse drug reaction (Naranjo Algorithm - ADR Probability Scale) | Definitive ≥ 9 | 8 (13.56) |
Probable 5–8 | 31 (52.54) | |
Possible 1–4 | 14 (23.73) | |
Doubtful − 4 − 0 | 6 (10.17) | |
Causes of Adverse Drug Reaction | The drug product causes an undesirable reaction that is dose-related | 41 (69.49) |
A drug interaction causes an undesirable reaction that is not dose-related | 15 (25.42) | |
A safer drug product is required due to risk factors | 3 (5.08) | |
Non Adherence | Low adherence | 121 (34.47) |
Non-adherence reason | Simply forgetfulness | 68 (36.56) |
Inadequate instruction | 34 (18.28) | |
Inadequate availability of medication | 32 (17.20) | |
Fear of medication adverse events | 18 (9.68) | |
Feeling better or worse | 10 (5.38) | |
Due to workload/busy | 9 (4.84) | |
The patient prefers not to take | 5 (2.69) | |
The cost of medication to expensive | 5 (2.69) | |
Regimen complexity | 3 (1.61) | |
Disbelief in drug effectiveness | 1 ( 0.54) | |
Difficulty of administration | 1 (0.54) |