Fig. 1
From: Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2
Effect of AS-IV on CdCl2-induced renal injury. (A) Changes in body weight of rats (n = 7). Data are shown as mean ± s.d. Two-tailed t-test. * p < 0.05, ** p < 0.01, *** p < 0.001. (B) SCR levels in rats after 14 days. Data are shown as mean ± s.d. n = 7. Two-tailed t-test. p < 0.001, Con vs. CdCl2, p = 0.0237, AS-IV -L vs. CdCl2, p < 0.001 AS-IV -H vs. CdCl2. (C) BUN levels in rats after 14 days. Data are shown as mean ± s.d. n = 7. Two-tailed t-test. p < 0.001, Con vs. CdCl2, p = 0.0879, AS-IV -L vs. CdCl2, p < 0.001 AS-IV -H vs. CdCl2. (D) 24-hour urine protein levels in rats after 14 days. Data are shown as mean ± s.d. n = 7. Two-tailed t-test. p < 0.001, Con vs. CdCl2, p = 0.0276, AS-IV -L vs. CdCl2, p < 0.001 AS-IV -H vs. CdCl2. (E) Morphologic observation and HE staining were used to observe histologic abnormalities in renal tissues. Scale bar, 50 μm.
