Fig. 5
A PPI network of DEGs was constructed and hub genes were analyzed. (a) PPI network and top hub genes (Kif4a and Mki67) are highlighted in yellow. (b) Flower plot showing the results of 12 algorithms to identify hub genes. (c) Overview of the GeneMANIA network: the black circle represents a GeneMANIA input and the gray circle represents a GeneMANIA hub. (d) Relationship between the hub genes expression level in different cancer types. (e) Using different normal tissues to compare the Kif4a and Mki67. (f) Different cell lines analyzed for variations in hub gene expression levels. (g) In TCGA, PRAD hub genes (Kif4a and Mki67) showed a positive correlation with their expression values. (h) Relationship between hub genes expression in the normal tissues. (i) Hub genes expression in cells and their relationship.
