Fig. 6
Endothelial-CHRM3 contribute to ACh-mediated vasodilation. (a) Acetylcholine (ACh), (b) SNP, and (c) SKA-31 dose–response curves were assessed by wire myography in aortic segments preconstricted with phenylephrine (PE, 100 nmol/L) from Chrm3f/f and VECre:Chrm3f/f mice. N = 7–8 male and female mice per genotype, repeated measures ANOVA with Fisher’s LSD post hoc test, *P < 0.05 significantly different from corresponding values in Chrm3f/f mice. Red lines and squares represent knockout and black lines and circles represent control mice. Individual data points represent average aortic relaxation (as % of initial preconstriction) of 7–8 mice. Means are ± SEM.
