Table 3 Pharmacokinetic parameters of CBD and 7-OH-CBD for all study participants (n=11).

From: A high-fat meal significantly impacts the bioavailability and biphasic absorption of cannabidiol (CBD) from a CBD-rich extract in men and women

Pharmacokinetic parameter

Fasted

Fed

GMR

CBD

   

Cmax (ng/mL)

1.9 (1.5-2.4)

32.8 (25.9-41.6)

17.4 (12.4-24.2)

AUC0-48 (ng.h/mL)

22.6 (19.2-26.7)

220.7 (187.4-260.0)

9.7 (7.7-12.3)

Tmax (h)

5.0 (0.8-6.0)

10.0 (1.5-12.0)

N.A.

7-OH-CBD

   

Cmax (ng/mL)

1.9 (1.5-2.5)

7.8 (6.0-10.0)

4.0 (2.8-5.8)

AUC0-48 (ng.h/mL)

23.0 (19.6-27.1)

102.9 (87.6-121.0)

4.5 (3.6-5.6)

Tmax (h)

3.0 (1.0-6.0)

6.0 (5.0-12.0)

N.A.

  1. Cmax and AUC0-48 are presented as geometric mean (90% CI), Tmax as median (range); AUC0-48 area under the curve from zero to 48 hours, Cmax maximum measured plasma concentration, CI confidence interval, GMR geometric mean ratio (90% CI), N.A. not applicable, Tmax time to maximum plasma concentration.
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