Table 4 Pharmacokinetic parameters of CBD and 7-OH-CBD in female (n=5) and male (n=6) participants.

From: A high-fat meal significantly impacts the bioavailability and biphasic absorption of cannabidiol (CBD) from a CBD-rich extract in men and women

Pharmacokinetic parameter

Female

Male

Fasted

Fed

GMR

Fasted

Fed

GMR

CBD

Cmax (ng/mL)

2.1 (1.5-2.9)

28.1 (20.2-39.3)

13.4 (8.4-21.5)

1.7 (1.1-2.4)

40.9 (28.0-59.7)

24.7 (14.4-42.2)

AUC0-48 (ng.h/mL)

25.3 (20.2-31.8)

215.5 (171.7-270.4)

8.5 (6.2-11.7)

19.8 (14.7-26.7)

222.2 (164.6-300.0)

11.2 (7.3-17.2)

Tmax (h)

5.0 (2.5-5.0)

10.0 (6.0-12.0)

N.A.

5.8 (0.8-6.0)

5.0 (1.50-10.0)

N.A.

7-OH-CBD

Cmax (ng/mL)

2.1 (1.4-3.2)

9.6 (6.3-14.5)

4.6 (2.6-8.2)

2.0 (1.4-2.9)

7.0 (4.8-10.2)

3.5 (2.1-6.0)

AUC0-48 (ng.h/mL)

28.1 (22.2-35.7)

123.6 (97.4-156.8)

4.4 (3.1-6.2)

18.9 (13.9-25.6)

86.5 (63.6-117.6)

4.6 (3.0-7.1)

Tmax (h)

3.0 (2.0-5.0)

10.0 (5.0-12.0)

N.A.

3.8 (1.0-6.0)

6.0 (5.0-10.0)

N.A.

  1. Cmax and AUC0-48 are presented as geometric mean (90% CI), Tmax as median (range); AUC0-48 area under the curve from zero to 48 hours, Cmax maximum measured plasma concentration, CI confidence interval, GMR geometric mean ratio (90% CI), N.A. not applicable, Tmax time to maximum plasma concentration.
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