Table 1 Oxypurine kinetics of patients with type 1 xanthuria.
From: Pseudogenization of the Slc23a4 gene is necessary for the survival of Xdh-deficient mice
The urinary xanthine/creatinine ratio (mmol/mol Cr) | The urinary hypoxanthine/creatinine ratio (mmol/mol Cr) | The urinary hypoxanthine/xanthine ratio | Plasma xanthine (μmol/L) | Plasma hypoxanthine (μmol/L) | Ref | ||
|---|---|---|---|---|---|---|---|
Ichida 1997 | #1 | 110 | 89 | 0.809 | 23.6 | 5.9 | |
#2 | 85.7 | 57.8 | 0.674 | 15.8 | 7.3 | ||
#3* | 132 | 1.5 | 0.011 | 85 | 0.8 | ||
#4 | 108.2 | 38.9 | 0.360 | 38.5 | 1.6 | ||
Gok, 2003 | III-3 | 64.2 | 28.4 | 0.442 | 21.0 | 10.6 | |
III-1 | 227.2 | 28.5 | 0.125 | 14.2 | 14.2 | ||
Arikyants, 2007 | S.B | 259 | 54 | 0.208 | 18 | 13 | |
S.B. sis | 370 | 77 | 0.208 | 16 | 19 | ||
Jurecka, 2010 | 192 | 44 | 0.229 | ||||
Stiburkova, 2012 | P1 | 190 | 64 | 0.337 | |||
P2 | 170 | 89 | 0.524 | ||||
Eggermann, 2013 | 193 | 65.0 | 0.337 | ||||
Mraz, 2015 | Case 1 | 164.5 | 74.4 | 0.452 | 14 | 31 | |
Case 2 | 349.3 | 138.0 | 0.395 | 9 | 0 | ||
Case 3 | 328.2 | 61.8 | 0.188 | 14 | 15 | ||
Iguchi, 2016 | 207.4 | 58.2 | 0.281 | 25.8 | 7.0 | ||
Xu, 2020 | 270 | 186 | 0.689 | ||||
Peretz, 2021 | F2V2 | 106 | 40 | 0.377 | |||
Goncalves, 2024 | * | 94.18 | 4.418 | 0.047 | |||
Maes, 2024 | 135 | 16 | 0.119 | ||||
Mean ± SEM | 187.8 ± 20.1 | 60.8 ± 9.7 | 0.375 ± 0.046 | 24.6 ± 5.9 | 10.4 ± 2.6 | ||
Hprt(high)Xdh(− / −)Slc23a4(− / −) mice fed a normal diet | 3761 ± 299 | 433.5 ± 86.4 | 0.115 ± 0.289 | 121.9 ± 10.4 | 35.0 ± 4.2 | ||
Hprt(high)Xdh(− / −)Slc23a4(− / −) mice fed a purified diet | 1520 ± 260 | 61.5 ± 34.6 | 0.040 ± 0.116 | 65.4 ± 5.0 | 24.1 ± 4.0 | ||
