Fig. 3 | Scientific Reports

Fig. 3

From: Spinal CRH facilitates the micturition reflex via the CRH2 receptor in rats with normal bladder and bladder outlet obstruction

Fig. 3

Effect of intrathecal CRH and CRH antagonists in BOO rats at day 14 post-operatively. (A) The bladder pressure trace following intrathecal administration of CRH alone (upper trace) and pre-administration of Antalarmin (middle trace) and Antisauvagine-30 (lower trace) followed by CRH application. (B) Comparison of voiding volume following the intrathecal administration of CRH alone, Antalarmin alone, and Antisauvagine-30 alone, or following the pre-administration of vehicle, Antalarmin, and Antisauvagine-30 followed by CRH administration. *p < 0.05 : significant difference compared to the base (Wilcoxon matched-pairs signed rank test).

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