Table 6 Effect size of HSI levels and reversion to normoglycemia from prediabetes in prespecified and exploratory subgroups.

From: Nonlinear relationship between hepatic steatosis index and reversion to normal glucose regulation in Chinese adults with prediabetes

Characteristic

No of participants

HR (95%CI) P value

P for interaction

Age (years)

  

0.6956

  < 30

596

0.97 (0.89, 1.06) 0.5243

 30–40

2598

0.95 (0.90, 1.00) 0.0660

 40–50

2436

0.91 (0.85, 0.98) 0.0086

 50–60

2552

0.91 (0.83, 0.99) 0.0246

  ≥ 60

3059

0.93 (0.86, 1.02) 0.1105

Gender

  

0.7773

 Male

7512

0.92 (0.89, 0.96) < 0.0001

 Female

3729

0.93 (0.88, 0.98) 0.0120

BMI (kg/m2)

  

0.7908

 < 25

5981

0.95 (0.89, 1.00) 0.0681

 25–30

4492

0.94 (0.87, 1.01) 0.0888

 ≥ 30

768

1.00 (0.84, 1.19) 0.9892

Smoking status

  

0.8082

 Current smoker

2220

0.95 (0.88, 1.02) 0.1435

 Ever smoker

485

0.94 (0.82, 1.08) 0.3764

 Never smoker

8536

0.92 (0.89, 0.96) < 0.0001

Drinking status

  

0.9745

 Current drinker

3292

0.92 (0.86, 0.98) 0.0094

 Ever drinker

1827

0.93 (0.86, 1.00) 0.0485

 Never drinker

6122

0.92 (0.88, 0.96) 0.0001

Family history of diabetes

  

0.2990

 No

10975

0.93 (0.90, 0.96) < 0.0001

 Yes

266

0.84 (0.70, 1.01) 0.0627

  1. Note 1: Above model was adjusted for age, gender, SBP, DBP, drinking status, family history of diabetes, smoking status, FPG, HDL-C, BUN, LDL-C, Scr, and TG.
  2. Note 2: The model is not adjusted for the stratification variable in each case.
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