Fig. 10 | Scientific Reports

Fig. 10

From: Sphingosine kinase 1 promotes M2 macrophage infiltration and enhances glioma cell migration via the JAK2/STAT3 pathway

Fig. 10

In vivo experiment. (A–B) Results in nude mice after anesthesia for tumor formation and after tumor stripping. (C) Volume and weight were measured after tumor removal. (D) Western blotting experiments in vivo illustrated that AG490 reversed the SPHK1 overexpression-induced elevation of p-JAK2/JAK2 and p-STAT3/STAT3. (E) CD206 and TGF-β1 expression level were detected after extracting RNA from tumor tissues. The experiment was performed thrice, and the results are presented as mean and standard deviation. Statistical significance was determined at p < 0.05.

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