Fig. 9 | Scientific Reports

Fig. 9

From: Sphingosine kinase 1 promotes M2 macrophage infiltration and enhances glioma cell migration via the JAK2/STAT3 pathway

Fig. 9

SPHK1 facilitates glioma progress by the JAK2/STAT3 pathway. (A–B) The JAK2/STAT3 pathway inhibitor AG490 reverses the overactivation of glioma cell migration ability due to SPHK1 overexpression. (C) AG490 reversed the abnormal elevation of p-JAK2/JAK2 and p-STAT3/STAT3 induced by SPHK1 overexpression. The experiment was performed thrice, and the results are presented as mean and standard deviation. Statistical significance was determined at p < 0.05.

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