Fig. 3 | Scientific Reports

Fig. 3

From: Mechanistic elucidation of human pancreatic acinar development using single-cell transcriptome analysis on a human iPSC differentiation model

Fig. 3

Identification of novel marker candidates for pancreatic acinar progenitor cells. (A) Dot plots of DEGs (|log2FC|> 1, P value < 0.01) among clusters of pancreatic endoderm cells (cluster 12), acinar progenitor cells (cluster 11), acinar cells (cluster 5), endocrine cells (cluster 2), and duct cells (cluster 3). (B) Volcano plots of DEGs (|log2FC|> 1, P value < 0.01) comparing gene expression of pancreatic endoderm cells (cluster 12) versus acinar progenitor cells (cluster 11; left panel) and acinar progenitor cells (cluster 11) versus acinar cells (cluster 5; middle panel) and the Venn diagram (right panel). (C) Distribution of cells expressing the four candidate markers for acinar progenitor cells, REG4, BGN, COL1A2, and HAPLN1. (D) Expression pattern of REG4 and PRSS1 among the 3 clusters based on DEGs (|log2FC|> 1, P value < 0.01).

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