Fig. 3
Intercellular crosstalk analysis. (A-B) The interactions of various cells(A) and of 5 cell types(A) of concern (New PT1, New PT2, NewPT1/3, proliferative PT and fibroblasts) in sham, AKI (IRI_4h, IRI_12h, IRI_2d) and CKD (IRI_6w) groups. The dots represent different cell types, each depicted in a distinct color. The arrows indicate intercellular interactions, originating as ligands and terminating as receptors. Furthermore, the lines are color-matched to the cell type harboring the ligands. (C) Information flow of enriched signaling pathway in sham, AKI and CKD groups. The bold font indicates a greater proportion within the CKD group. (D) Outgoing and incoming communication patterns of 21 cell types. The cell clusters and signaling pathways of concern are indicated in bold font. (E) Significant ligand-receptor pairs within the LAMININ and PDGF signaling pathway. The terms Lama2 - Dag1 and Lama2 - (Itgav + Itgb8) denote the specific interaction between laminin alpha 2 (LAMa2) and its receptors, dystrophin-associated glycoprotein 1 (DAG1), and integrin alpha V beta 8. The term Pdgfd – Pdgfrb refers to the interaction between platelet-derived growth factor D (PDGFD) and platelet-derived growth factor receptor β (PDGFRβ).
