Table 1 Characteristics of LifeGene study participants. Means, standard deviation (SD), and proportions (percentage).

From: Early life factors and variation in adult kidney function in the Swedish LifeGene cohort

 

Total

(N = 12 167)

Men

(N = 5138)

Women

(N = 7029)

P-value

Early life factors

 

GA, weeks

40 (2)

40 (2)

40 (2)

0.470

BW, g

3517 (520)

3596 (533)

3458 (503)

< 0.001

BL, cm

50 (2)

51 (2)

50 (2)

< 0.001

HC, cm

35 (2)

35 (2)

34 (2)

< 0.001

BWz

0.02 (1.35)

0.27 (1.35)

-0.17 (1.33)

< 0.001

Prematurity, yes

8.5 (1040)

8.9 (456)

8.3 (584)

0.270

SGA, yes

2.5 (304)

2.4 (122)

2.6 (182)

0.455

LGA, yes

2.5 (304)

2.5 (129)

2.5 (175)

0.939

Placenta weight (PW), g†

614 (141)

630 (150)

603 (134)

< 0.001

BW/PW†

5.9 (1.0)

5.9 (1.0)

5.9 (1.0)

0.616

Maternal age, years

29 (5)

30 (5)

29.4 (4.8)

0.999

Maternal BMI, early pregnancy, kg/m2†

21.4 (2.6)

21.5 (2.8)

21.4 (2.6)

0.116

Maternal BMI at delivery, kg/m2†

26.4 (3.1)

26.5 (3.2)

26.4 (3.1)

0.137

Maternal weight gain, kg†

13.8 (4.4)

13.9 (4.3)

13.8 (4.3)

0.192

Adult life factors

 

Age, years

29 (6)

30 (6)

29 (6)

< 0.001

BMI, kg/m2

23.5 (3.3)

24.5 (3.0)

22.8 (3.3)

< 0.001

FMI, kg/m2

5.5 (2.5)

4.2 (1.9)

6.5 (2.4)

< 0.001

Smoking1

   

0.165

- Yes

36.8 (4472)

36.0 (3228)

37.3 (4303)

- No

24.4 (2969)

26.3 (1236)

23.0 (2279)

- Missing

38.8 (4726)

37.7 (1937)

39.7 (2789)

Snuff1 (nicotine patches)

   

< 0.001

- Yes

23.7 (2885)

34.7 (1785)

44.4 (110)

- No

36.3 (4417)

31.3 (1606)

40.0 (2811)

- Missing

40.0 (4865)

34.0 (1747)

44.4 (3118)

Diabetes, yes

0.3 (33)

0.4 (18)

0.2 (15)

0.151

Kidney disease, yes

0.7 (91)

0.8 (39)

0.7 (52)

0.903

SBP, mmHg

115 (11)

121 (10)

110 (10)

< 0.001

DBP, mmHg

69 (8)

72 (9)

67 (8)

< 0.001

MAP, mmHg

84 (9)

88 (8)

82 (8)

< 0.001

WC, cm

80 (10)

86 (8)

75 (8)

< 0.001

Kidney function in adult life

 

eGFRcr, mL/min/1.73m2

83 (15)

72 (10)

91 (13)

< 0.001

eGFRcys ‡, mL/min/1.73m2

102 (21)

97 (18)

105 (22)

< 0.001

eGFRcr/eGFRcys‡

1.18 (0.27)

1.29 (0.26)

1.12 (0.25)

< 0.001

CKD

4.0 (483)

9.0 (464)

0.3 (19)

< 0.001

  1. Abbreviations: BMI, body mass index; FMI, fat mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; WC, waist circumference; GA, gestational age, BW, birth weight; BL, birth length; HC, head circumference; BWz, birth weight sex-specific z-score; SGA, small for gestational age; LGA, large for gestational age; PW, placenta weight; eGFRcr, estimated creatinine-based glomerular filtration rate; eGFRcys, estimated cystatin C based glomerular filtration rate; CKD, chronic kidney disease where eGFRcr is below 60mL/min/1.73m2.
  2. Smoking1: Question: Have you ever smoked at least one cigarette?.
  3. Snuff1: Question: Have you ever used five nicotine patches in your life?.
  4. †Data in 2 499 individuals, 1482 women and 1017 men.
  5. ‡Data in 2 395 individuals, 1461 women and 934 men.
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