Table 2 Time-varying Effect and Time-constant Effect of Vaccine.

From: Joint analysis of time-varying effect of vaccine and antiviral drug for preventing severe complications and mortality

Vaccine Type

Time

(months)

Complication

Death

Time-varying Effect

Time-constant

Effect

Time-varying Effect

Time-constant Effect

PE(t)⋆

(95% CI)

PE†

(95% CI)

PE(t)⋆

(95% CI)

PE†

(95% CI)

CoronaVac

1 dose

t = 0.5

0.099

(0.000,0.202)

0.099

(0.000,0.188)

0.131

(0.049,0.234)

0.132

(0.034,0.220)

t = 6

0.099

(0.000,0.202)

0.131

(0.038,0.221)

2 doses

t = 0.5

0.328

(0.265,0.403)

0.332

(0.261,0.397)

0.305

(0.238,0.382)

0.317

(0.241,0.385)

t = 6

0.328

(0.265,0.403)

0.302

(0.235,0.378)

3 doses

t = 0.5

0.446

(0.382,0.520)

0.453

(0.381,0.517)

0.499

(0.434,0.572)

0.537

(0.467,0.597)

t = 6

0.446

(0.382,0.520)

0.499

(0.434,0.572)

4 doses

t = 0.5

0.594

(0.457,0.731)

0.603

(0.434,0.721)

0.809

(0.704,0.892)

0.773

(0.626,0.862)

t = 6

0.594

(0.457,0.731)

0.608

(0.417,0.786)

Comirnaty

1 dose

t = 0.5

0.146

(−0.148,0.335)

0.128

(−0.153,0.341)

0.134

(−0.171,0.353)

0.123

(−0.177,0.347)

t = 6

0.146

(−0.148,0.335)

0.134

(−0.171,0.353)

2 doses

t = 0.5

0.386

(0.291,0.498)

0.397

(0.281,0.494)

0.387

(0.284,0.509)

0.400

(0.273,0.501)

t = 6

0.386

(0.291,0.498)

0.377

(0.276,0.497)

3 doses

t = 0.5

0.658

(0.588,0.730)

0.665

(0.586,0.729)

0.699

(0.623,0.775)

0.717

(0.633,0.782)

t = 6

0.658

(0.588,0.730)

0.699

(0.623,0.775)

4 doses

t = 0.5

1.000

(0.999,1.000)

0.829

(0.588,0.929)

1.000

(0.999,1.000)

0.869

(0.592,0.958)

t = 6

0.713

(0.509,0.886)

0.733

(0.488,0.923)

  1. ⋆Protective efficacy (PE(t)) \(t\) months after its administration based on the time-varying model.
  2. †Protective efficacy (PE) based on the constant effect model.
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