Fig. 7 | Scientific Reports

Fig. 7

From: Hypothermia regulates mitophagy and apoptosis via PINK1/Parkin-VDAC 3 signaling pathway during oxygen-glucose deprivation/recovery injury

Fig. 7

Cellular signal pathway diagram of hypothermia at 2 h after temperature intervention. On the one hand, hypothermia promoted the expression of Cleaved PINK1 at first, and then recruited Parkin onto the outer mitochondrial membrane, thereby decreasing the expression of VDAC3 as well as SQSTM/p62, and then increased the ratio of LC3B II/LC3B I and reduced the release of Cyt C via decreasing mPTP opening, subsequently reduced the expression of downstream proapoptotic proteins such as cleaved caspase3 and caspase3 during OGD/R. Finally, hypothermia provided neuroprotective effects via alleviating apoptosis and promoting mitophagy. On the other hand, hypothermia increased the expression of Bcl-2 and Beclin-1 through disrupting the interaction between Bcl-2 and Beclin-1 during OGD/R, alleviating apoptosis and promoting mitophagy in the end. Thus, hypothermia provided neuroprotective effects via activating the PINK1/Parkin-VDAC3 signaling pathway.

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