Fig. 8 | Scientific Reports

Fig. 8

From: Hypothermia regulates mitophagy and apoptosis via PINK1/Parkin-VDAC 3 signaling pathway during oxygen-glucose deprivation/recovery injury

Fig. 8

Cellular signal pathway diagram of hypothermia at 4 h after temperature intervention. Under the condition of OGD/R, hypothermia inhibited Parkin recruitment to mitochondria and magnified mPTP opening via the high expression of VDAC3, and then aggravated the release of Cyt C through mPTP. Hypothermia also increased the expression of SQSTM/p62 and Beclin-1, but did not change the ratio of LC3B II/LC3B I. Finally, hypothermia induced apoptosis but did not promote mitophagy. The recruitment of Parkin from cytoplasm to mitochondria might be relevant to the overexpression of Bcl-2. (Cleaved PINK1, cPINK1; OMM, outer mitochondrial membrane; IMS, inner mitochondrial stroma; IMM, inner mitochondrial membrane). Red represents the different effects between 2 h and 4 h after hypothermia intervention.

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