Fig. 4 | Scientific Reports

Fig. 4

From: Establishment and characterization of three gemcitabine-resistant human intrahepatic cholangiocarcinoma cell lines

Fig. 4

GEM resistance was independent of PI3K/Akt and EMT pathway in ICC cell lines. (A) Detection of the mRNA expression levels of the EMT pathway, PI3K/Akt axis, IGF-1R, p53R2, Bcl-2, and Bax between the parental and resistant ICC cells. (B) Western blot analysis of protein expression related to the EMT pathway and the PI3K/Akt signaling axis. HCCC-9810-P: HCCC-9810 parental cell; HCCC-9810-R: HCCC-9810 GEM-resistant cell. *P<0.05; **P<0.01 versus parental ICC cells.

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