Fig. 4
From: A novel MRI contrast agent NaGdF4@PEG–CLS@MMP-13 NPs for detecting articular cartilage injury
In vivo MRI detection of cartilage injuries by NaGdF4@PEG–CLS@MMP13 CBP NPs. (a) T1-weighted MRI images of the knee of the cartilage-injured rat obtained before and after the intra-articular injections of Gd-DTPA (top), NaGdF4@PEG–CLS NPs (middle), and NaGdF4@PEG–CLS@MMP13 CBP NPs (bottom). The cartilage and injured site were denoted by the blue and red arrows, respectively; (b–e) ΔSNR changes obtained from the T1-weighted MRI images of the injured site (b, c) and cartilage (d, e). Data were presented as mean ± SEM (n = 5 per group). *p < 0.05, **p < 0.01 compared to the Gd-DTPA group; #p < 0.05, ##p < 0.01 compared to the NaGdF4@PEG–CLS NPs group.
