Fig. 1 | Scientific Reports

Fig. 1

From: PPM1B degradation mediated by TRIM25 ubiquitination modulates cell cycle and promotes gastric cancer growth

Fig. 1

Reduced PPM1B expression in GC is associated with poor prognosis. (A,B) Expression of PPM1B in GC and adjacent normal tissues was detected by IHC. Representative images and IHC scores are shown. (C) The mRNA expression of PPM1B in 100 GC patients. (D) Expression of PPM1B in GC and adjacent normal tissues was detected by WB. (E) PPM1B mRNA expression in 108 gastric tissue samples from the GEO dataset (GSE26899). (F) Prognostic value of PPM1B was assessed in the GEO cohort. (G) The clinical significance of PPM1B expression on overall survival in 100 GC patients was confirmed by Kaplan-Meier survival analysis in the central cohort of this study. All **P < 0.01 and ***P < 0.001.

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