Fig. 3

Predictive accuracy of DL-XAI clock and benchmarking. (a) Scatterplot of donors’ predicted age of naïve CD4 + T meta-cells (y-axis) against donors’ chronological age (x-axis). The predicted age of a given donor (taking the median prediction over all meta-cells of a given donor) was obtained by DL-XAI clock, the elastic net model with PPI genes, the elastic net model with all genes and the GLMgraph model, respectively. (b) Scatterplot of predicted age of naïve CD4T meta-cells (y-axis) against meta cells’ chronological age (x-axis). The predicted age was obtained by DL-XAI clock, the elastic net model with PPI genes, the elastic net model with all genes, and the GLMgraph model, respectively. PCC represents Pearson correlation coefficient, MAE represents mean absolute error, P-value was obtained from Pearson correlation analysis. (c) Barplots displaying the MAE and PCC of the 4 methods plus a Random Forest (RF) model, and for the analyses performed at the level of donors (left panels) and meta-cells (right panels).