Fig. 5
The ribosomal gene module is associated with age independently of cell-type. (a) Violin plots display the -log10 transformed P-values with P-values obtained from a Spearman correlation test between gene expression and age, for two groups gene: Ribosome = the union of 78 ribosomal genes selected by PGExplainer across all cell-types, Other = all other genes. The P-value in the violin plot indicates whether the difference between the two groups is statistically significant, and is derived from a one-tailed Wilcoxon-rank sum test. (b) Heatmap of the correlation of 78 ribosomal genes with age in these four cell types. SCC denotes spearman’s rank correlation coefficient, p-values have been adjusted using the Benjamini-Hochberg (BH) procedure to yield FDR values. (c) Bar chart illustrates the fraction of 78 ribosomal genes that are either upregulated or downregulated across different cell types. The fraction is calculated by dividing the number of upregulated or downregulated ribosomal genes by the total of 78 ribosomal genes. The red bars represent upregulated genes, and the blue bars represent downregulated genes. The P-value is obtained from a one-tailed binomial distribution.
