Table 2 Changes in cholesterol and non-cholesterol sterols concentrations in HDL, HDL particle subclasses and gene expressions through trimesters in the group of pregnant women with recommended weight gain.

From: Associations of excessive gestational weight gain with changes in components of maternal reverse cholesterol transport and neonatal outcomes

 

1st Trimester

2nd Trimester

3rd Trimester

P value

HDL-C (mmol/L)#

1.67 ± 0.33

1.89 ± 0.36a*

1.79 ± 0.32a*

 < 0.001

Desmosterol in HDL (μmol/L)

0.26 (0.21–0.30)

0.26 (0.20–0.34)

0.32 a*b* (0.25–0.42)

 < 0.001

7-Dehydrocholesterol in HDL (μmol/L)

0.38 (0.32–0.45)

0.40 (0.33–0.46)

0.41 (0–33-0–48)

0.551

Lathosterol in HDL (μmol/L)

1.16 (0.71–1.58)

1.35 (0.81–1.80)

1.60a*,b* (1.01–2.34)

0.001

Campesterol in HDL (μmol/L)

0.45 (0.27–0.71)

0.47 (0.35–0.79)

0.45 (0.36–0.71)

0.167

β-Sitosterol in HDL (μmol/L)

6.30 (4.71–7.88)

5.91 (4.81–7.18)

5.96 (4.60–8.43)

0.285

HDL 2b (%)

49.13 (44.19–53.16)

51.37 (45.98–54.38)

50.02 (47.45–52.95)

0.050

HDL 2a (%)

21.16 (19.92–22.65)

20.85 (19.32–22.16)

20.70 (19.39–22.10)

0.302

HDL 3a (%)

13.73 (12.62–15.65)

13.49 (11.87–14.97)

13.55 (11.57–14.58)

0.093

HDL 3b (%)

7.87 (6.56–9.13)

7.24 (6.52–8.67)

7.90 (6.85–8.75)

0.161

HDL 3c (%)

7.37 (5.20–11.22)

6.47 (5.02–10.73)

6.94 (5.08–10.24)

0.689

SCARB1 mRNA

0.86 (0.65–1.20)

0.93 (0.68–1.16)

0.96 (0.71–1.13)

0.864

ABCA1 mRNA

0.88 (0.62–1.22)

0.96 (0.74–1.34)

0.97 (0.72–1.16)

0.360

ABCG1 mRNA

0.90 (0.72–1.33)

0.90 (0.74–1.23)

0.88 (0.68–1.32)

0.281

  1. Data are presented as medians (interquartile ranges) and compared using the Friedman test (non-parametric repeated-measures ANOVA) with the Wilcoxon post hoc test and Bonferroni correction. Pairwise comparison: asignificantly different from the first trimester; bsignificantly different from the second trimester; *P < 0.017 (Bonferroni corrected). # Data are presented as means ± standard deviation and compared using repeated-measures ANOVA. Pairwise comparison: a mean difference significantly different from the first trimester; b mean difference significantly different from the second trimester; *P < 0.017 (Bonferroni corrected).