Table 2 Changes in cholesterol and non-cholesterol sterols concentrations in HDL, HDL particle subclasses and gene expressions through trimesters in the group of pregnant women with recommended weight gain.
1st Trimester | 2nd Trimester | 3rd Trimester | P value | |
|---|---|---|---|---|
HDL-C (mmol/L)# | 1.67 ± 0.33 | 1.89 ± 0.36a* | 1.79 ± 0.32a* | < 0.001 |
Desmosterol in HDL (μmol/L) | 0.26 (0.21–0.30) | 0.26 (0.20–0.34) | 0.32 a*b* (0.25–0.42) | < 0.001 |
7-Dehydrocholesterol in HDL (μmol/L) | 0.38 (0.32–0.45) | 0.40 (0.33–0.46) | 0.41 (0–33-0–48) | 0.551 |
Lathosterol in HDL (μmol/L) | 1.16 (0.71–1.58) | 1.35 (0.81–1.80) | 1.60a*,b* (1.01–2.34) | 0.001 |
Campesterol in HDL (μmol/L) | 0.45 (0.27–0.71) | 0.47 (0.35–0.79) | 0.45 (0.36–0.71) | 0.167 |
β-Sitosterol in HDL (μmol/L) | 6.30 (4.71–7.88) | 5.91 (4.81–7.18) | 5.96 (4.60–8.43) | 0.285 |
HDL 2b (%) | 49.13 (44.19–53.16) | 51.37 (45.98–54.38) | 50.02 (47.45–52.95) | 0.050 |
HDL 2a (%) | 21.16 (19.92–22.65) | 20.85 (19.32–22.16) | 20.70 (19.39–22.10) | 0.302 |
HDL 3a (%) | 13.73 (12.62–15.65) | 13.49 (11.87–14.97) | 13.55 (11.57–14.58) | 0.093 |
HDL 3b (%) | 7.87 (6.56–9.13) | 7.24 (6.52–8.67) | 7.90 (6.85–8.75) | 0.161 |
HDL 3c (%) | 7.37 (5.20–11.22) | 6.47 (5.02–10.73) | 6.94 (5.08–10.24) | 0.689 |
SCARB1 mRNA | 0.86 (0.65–1.20) | 0.93 (0.68–1.16) | 0.96 (0.71–1.13) | 0.864 |
ABCA1 mRNA | 0.88 (0.62–1.22) | 0.96 (0.74–1.34) | 0.97 (0.72–1.16) | 0.360 |
ABCG1 mRNA | 0.90 (0.72–1.33) | 0.90 (0.74–1.23) | 0.88 (0.68–1.32) | 0.281 |