Table 1 Sensitivity to AM-1488 of recombinant GlyRs expressed in HEK293.

From: Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide

GlyR

EC50 (µM)

nH

Maximal effect (% potentiation, 50 µM AM-1488)

n

α1

1.1 ± 0.1

0.91 ± 0.10

1262 ± 143

6

α1β

1.8 ± 0.1

1.10 ± 0.05

1454 ± 243

5

α2

2.4 ± 0.7

0.84 ± 0.20

1112 ± 143

5

α2β

1.3 ± 0.1

1.84 ± 0.29

995 ± 205

5

α3

2.1 ± 0.5

1.39 ± 0.30

1501 ± 172

6

α3β

3.0 ± 0.1

1.31 ± 0.05

1774 ± 201

7

  1. Differences were not significant. ANOVA followed by Bonferroni post hoc test.
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