Table 2 Single channel parameters.
From: Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide
GlyR | Amplitude (pA) | Conductance (pS) | NPo | |
|---|---|---|---|---|
α1 WT | Glycine 15 µM | 4.7 ± 0.2 | 73.3 ± 2.9 | 0.28 ± 0.07 |
+AM-1488 0.5 µM | 4.3 ± 0.2 | 72.1 ± 4.2 | 0.60 ± 0.09 * | |
+AM-1488 10 µM | 4.9 ± 0.3 | 82.2 ± 5.5 | 0.71 ± 0.05 ** | |
α3 WT | Glycine 50 µM | 5.4 ± 0.04 | 90.9 ± 0.6 | 0.03 ± 0.01 |
+AM-1488 10 µM | 5.4 ± 0.07 | 91.4 ± 1.1 | 0.56 ± 0.04*** | |
α3 S346E | Glycine 50 µM | 3.5 ± 0.07 | 58.1 ± 1.2 | 0.04 ± 0.01 |
+AM-1488 10 µM | 3.5 ± 0.06 | 59.7 ± 0.8 | 0.52 ± 0.06*** |
