Table 3 Sensitivity to glycine of wild-type and mutated α3GlyRs expressed in HEK293.

From: Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide

α3GlyR

EC50(µM)

nH

Imax(pA)

n

WT

88 ± 15

1.50 ± 0.37

3168 ± 969

6

F13A

1562 ± 175*

2.36 ± 0.58

1323 ± 174

6

L14A

1012 ± 140

1.22 ± 0.15

2529 ± 1099

6

L83A

383 ± 20

2.27 ± 0.30

1511 ± 441

4

R27A

1104 ± 19

2.62 ± 0.11

2390 ± 281

7

  1. Statistical comparisons: ANOVA followed by Bonferroni post hoc test. EC50: WT vs. F13A, *, p < 0.05; nH: No significant differences were detected; Imax: No significant differences were detected.
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