Fig. 3

ROC curve using p-tau217 or p-tau181 for predicting Aβ status using PET. ROC curve analysis of p-tau217 and p-tau181 for predicting Aβ status in the Cohort 1 (A–C) and Cohort 2 (D–F) subgroups. ROC curves for p-tau217 and p-tau181 are compared in the CU (A and D), MCI (B and E), and dementia (C and F) groups. *AUCs of different ROC curves compared using the DeLong method. CU, cognitive unimpaired; MCI, mild cognitive impairment; P-tau, phosphorylated tau; AUC, area under the curve; ROC, receiver operating characteristic; PET, positron emission tomography; Aβ, amyloid beta.