Fig. 4

ROC curve using p-tau217 or p-tau181 for predicting cognitive stage transition. ROC curve analysis of p-tau217 and p-tau181 for discriminating a cognitive stage transition in total (A), CU (B), and MCI (C) patients over 3 years in cohort 1. *AUC of different ROC curves compared using the DeLong method. CU, cognitive unimpaired; MCI, mild cognitive impaired; P-tau, phosphorylated tau; ROC, receiver operating characteristic; ROC, receiver operating characteristic.