Table 2 Comparisons of observing indexes between pre-treatment and post-treatment in two groups [(\(\overline x\)± s), n (%), M (P25,P75)]

From: Negative pressure wound therapy promotes wound healing by down-regulating miR-155 expression in granulation tissue of diabetic foot ulcers

Variables

NPWT

Non-NPWT

Number of patients

  

Pre-treatment

40

20

Post-treatment

40

20

ULA, cm2

  

Pre-treatment

10.6 ± 3.1

10.4 ± 2.9

Post-treatment

7.9 ± 2.9

9.3 ± 3.0

FPG, mmol/L

  

Pre-treatment

11.1 ± 2.9

10.9 ± 3.1

Post-treatment

8.3 ± 2.1b

8.5 ± 1.9b

ABI

  

Pre-treatment

1.07 ± 0.13

1.12 ± 0.14

Post-treatment

1.08 ± 0.13

1.11 ± 0.13

CRP, mg/dl

  

Pre-treatment

39.2 ± 12.4

38.8 ± 11.6

Post-treatment

18.8 ± 7.9b

30.5 ± 12.4a

WBC, ×109

  

Pre-treatment

11.2 ± 4.4

10.3 ± 3.9

Post-treatment

8.5 ± 2.2b

9.3 ± 2.7a

ESR, mm/h

  

Pre-treatment

39.7 ± 16.5

40.1 ± 17.3

Post-treatment

33.8 ± 15.7

35.6 ± 16.4

Hb, g/L

  

Pre-treatment

114 ± 16

116 ± 15

Post-treatment

113 ± 15

116 ± 14

Alb, g/L

  

Pre-treatment

36.1 ± 3.5

35.7 ± 3.3

Post-treatment

35.8 ± 3.4

36.8 ± 3.5

T-IL-1β, pg/ml

  

Pre-treatment

15.7 ± 7.2

14.2 ± 6.9

Post-treatment

6.1 ± 3.4b

9.8 ± 4.8a

T-IL-6, pg/ml

  

Pre-treatment

80.3 ± 16.6

78.1 ± 17.9

Post-treatment

40.7 ± 11.3b

57.4 ± 15.2a

T-IL-4, pg/ml

  

Pre-treatment

4.9 ± 1.5

5.1 ± 1.8

Post-treatment

10.2 ± 3.2b

8.5 ± 2.9a

T-IL-10, pg/ml

  

Pre-treatment

5.3 ± 2.7

5.7 ± 2.5

Post-treatment

16.4 ± 3.5b

9.4 ± 2.6a

T-miR-155

  

Pre-treatment

6.83 (2.15–15.72)

7.15 (2.52–19.07)

Post-treatment

4.12 (1.22–14.85)a

6.32 (1.96–17.45)

T-FGF7

  

Pre-treatment

0.504 ± 0.119

0.491 ± 0.122

Post-treatment

0.796 ± 0.125a

0.524 ± 0.127

  1. Notes: Data presented as mean ± SD or median with IQR. The P-values were evaluated by paired t test.
  2. Abbreviations: NPWT, negative-pressure wound therapy group; Non-NPWT, without receiving NPWT group; ULA, ulcer area; FPG, fasting plasma glucose; ABI, ankle brachial index; CRP, C-reactive protein; WBC, white blood cell; ESR, erythrocyte sedimentation rate; Hb, hemoglobin; Alb, albumin; IL, interleukin; T-IL-1β, concentration of IL-1β in the supernatant of granulation tissue; T-IL-6, concentration of IL-6 in the supernatant of granulation tissue; T-IL-4, concentration of IL-4 in the supernatant of granulation tissue; T-IL-10, concentration of IL-10 in the supernatant of granulation tissue; T-miR-155, miR-155 expression in wound granulation tissue; T-FGF7, FGF7 protien expression in wound granulation tissue. vs. Pre-treatment in each group aP<0.05, bP<0.01.