Fig. 3 | Scientific Reports

Fig. 3

From: Neuroprotective mitochondria targeted small molecule restores synapses and the distribution of synaptic mitochondria in the hippocampus of APP/PS1 mice

Fig. 3

Chronic CP2 treatment restores the number of synapses in the hippocampus of the APP/PS1 mouse to the observed in a NTG mouse. (a) Representative 3D EM reconstructions of synaptic densities in NTG, APP/PS1, APP/PS1 + CP2 mice. The analysis was done using asymmetric synapses only. Synaptic densities are colored in green. Reconstruction was performed using SBFSEM images from three ROIs of the CA1 region using Espina software. Scale bar, 800 nm. (b) The number of asymmetric (blue bars) vs. symmetric (red bars) synapses in each ROI. Since most synapses were asymmetric, the symmetric synapses were excluded from the further analyses. (c) Quantitative analyses of synapses from NTG, APP/PS1 (A/P) and APP/PS1 + CP2 mice. Each data point represents one ROI. Each ROI has dimensions of 5 μm x 5 μm x 3.75 μm and the total volume of 93.75 μm3. Data were generated from one mouse per group using three ROIs per each mouse.

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