Fig. 5 | Scientific Reports

Fig. 5

From: Neuroprotective mitochondria targeted small molecule restores synapses and the distribution of synaptic mitochondria in the hippocampus of APP/PS1 mice

Fig. 5

Distribution of synaptic mitochondria in axons and dendrites in relationship to different type of DS. (a) Mitochondria distribution in axons and dendrites calculated per 10 synapses associated with different types of DS. The ratio (*) represents the number of dendritic mitochondria per axonal mitochondria per one DS of different type. (b) The ratio of dendritic/axonal mitochondria per the type of DS from (a) plotted for NTG (white), APP/PS1 (red) and APP/PS1 + CP2 (blue) mice. (c–f) Representative 3D EM reconstructions of dendrites (pink), axons (blue), and mitochondria (yellow) in the CA1 brain region of APP/PS1 (c, d) and APP/PS1 + CP2 (e, f) mice. #, thin DS; *, mushroom DS. Note mitochondria Type I and II in DS in (c,d) and MOAS in (e) and (f).

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