Fig. 7 | Scientific Reports

Fig. 7

From: Metformin modulates FJX1 via upregulation of Hsa-miR-1306-3p to suppress colon adenocarcinoma viability

Fig. 7

Schematic illustration of the proposed mechanism for modulation of hsa-miR-1306-3p and FJX1 using metformin. In COAD, the upregulation of FJX1 has been demonstrated to promote cell viability. Metformin treatment has been shown to increase the expression of tumor suppressor miRNAs, hsa-miR-1306-3p, which bind to FJX1 mRNA, leading to the inhibition of cell viability.

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