Fig. 2
The IRS is correlated with multiple clinical and immune features. (A) The distribution of the IRS across early (I/II) and late (III/IV) TNM stages. (B) The distribution of the IRS across high (G1/G2) and low (G3) differentiation group. (C) The distribution of the IRS across the TRU, PI, and PP. (D) Correlation analysis between the GSVA scores of the 50 Hallmark pathways and the IRS, the lung adenocarcinoma cohort comprised the TCGA-LUAD, GSE10245, GSE41271, GSE42127, GSE68465, and GSE72094). (E) Correlation analysis between immune cell infiltration levels and the IRS. Immune cell infiltration was computed using MCP-counter, and the lung adenocarcinoma cohort comprised the TCGA-LUAD, GSE10245, GSE14814, GSE41271, GSE42127, GSE68465, and GSE72094 cohorts. (F, G) Bar plot showing the correlation of CYT (F), GEP (G), VIGex (H) and the IRS, the LUAD cohort comprised the TCGA-LUAD, GSE10245, GSE14814, GSE41271, GSE42127, GSE68465, and GSE72094 cohorts (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001).
