Fig. 5
VEGFAhi mast cells promote tumor progression through various cellular interactions. (A) The distribution of D-score between HIRS and LIRS. The D-score was defined as the GSVA score (VEGFA + MC) minus the GSVA score (TNF + MC). (B) Kaplan–Meier curve showed the survival outcomes of patients with high and low D-score in the TCGA-LUAD cohort. (C–E) Heatmaps showed the relative importance of each cell population based on the computed network centrality measures of different signaling pathway networks. (C) VEGF. (D) CSF. (E) EGF. (F) Bubble plot showed representative cell-cell signaling pathways from mast cells to other cells in GSE189357. (G,H) The expression levels of VEGFA in seven cell types. (G) GSE171145; (H) GSE189357. (I) Heatmap showing the predicted ligand activity by NicheNet on genes highly expressed in mast cell. (J) Box plot showing the expression levels of VEGFA in mast cells between Non-MPR (Major Pathological Response) and MPR samples.
