Fig. 2 | Scientific Reports

Fig. 2

From: Immune dysregulation in COVID-19 induced ARDS in kidney transplant recipients revealed by single-cell RNA sequencing

Fig. 2

The potential role of S100A9+ megakaryocytes (MK) subpopulation in modulating the inflammatory response in ARDS. (A) Single-cell atlas displaying the single-cell landscape of MK . (B) Dot-line graph illustrating the abundance changes of different subpopulations within the MK group. (C) Density plot showing the markers of MK cell subpopulations. (D) Bar chart displaying the significantly enriched BP and KEGG signaling pathways of the MK cell subpopulation. (E) The gene set enrichment analysis revealed the activated signaling pathways in the MK subpopulation. (F) Stacked violin plots showing the expression levels of inflammatory cytokines by S100A9+ MK subpopulation. (G) Single-cell atlas mapping of MK progression trajectories and Monocle3 pseudotime values. (H) Gene regulatory network (GRN) graph showing the module of marker genes in MK subtypes. (I) The activity of transcription factors (TFs) in MK subtypes.

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