Fig. 5 | Scientific Reports

Fig. 5

From: Immune dysregulation in COVID-19 induced ARDS in kidney transplant recipients revealed by single-cell RNA sequencing

Fig. 5

XAF1+ Teff subpopulation promotes cell apoptosis, mediating the formation of ARDS inflammation after renal transplantation. (A) Single-cell atlas displaying the single-cell landscape of CD8+ T. (B) Stacked violin plots showing the expression of markers distinguishing CD8+ T subpopulations. (C) Density plot showing the markers of CD8+ T subpopulations. (D) Dot-line graph illustrating the abundance changes of different subpopulations within the CD8+ T group. (E) Bar chart displaying the significantly enriched BP and KEGG signaling pathways of the CD8+ T subpopulation. (F) The gene set enrichment analysis revealed the activated signaling pathways by XAF1+ Teff subpopulation. (G) Density plots showing the expression of proapoptotic genes in the CD8+ T subpopulation. (H) Single-cell atlas mapping of CD8+ T cell progression trajectories and Monocle3 pseudotime values. (I) GRN graph showing the module of marker genes in CD8+ T subpopulations. (J) Activity of TFs in CD8+ T cell subpopulations.

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