Table 1 Results of MR analysis of inflammatory factors and inflammatory disorders of the breast by inverse variance weighted method.

From: Genetic determinants of inflammatory cytokines and their causal relationship with inflammatory disorders of breast: a two-sample Mendelian randomization study

Exposure

Outcome

N.SNP

Method

OR (95% CI)

P

FDR adjusted P

CTACK/CCL27

Inflammatory disorders of breast

9

IVW

1.01 (0.83–1.24)

0.904

0.94

CTACK/CCL27

Inflammatory disorders of breast

9

IVW (multiplicative random effects)

1.01 (0.83–1.24)

0.904

0.94

Eotaxin

Inflammatory disorders of breast

13

IVW

0.98 (0.78–1.24)

0.892

0.892

Eotaxin

Inflammatory disorders of breast

13

IVW (multiplicative random effects)

0.98 (0.78–1.24)

0.892

0.892

GROa

Inflammatory disorders of breast

7

IVW

0.86 (0.74–0.99)

0.04

0.099

GROa

Inflammatory disorders of breast

7

IVW (multiplicative random effects)

0.86 (0.75–0.98)

0.026

0.099

MCP1

Inflammatory disorders of breast

5

IVW

0.88 (0.63–1.23)

0.458

0.938

MCP1

Inflammatory disorders of breast

5

IVW (multiplicative random effects)

0.88 (0.63–1.23)

0.458

0.938

MCP3

Inflammatory disorders of breast

2

IVW

0.91 (0.72–1.14)

0.408

0.408

MCP3

Inflammatory disorders of breast

2

IVW (multiplicative random effects)

0.91 (0.83–0.99)

0.033

0.067

MIG

Inflammatory disorders of breast

13

IVW

0.86 (0.74–1.00)

0.054

0.135

MIG

Inflammatory disorders of breast

13

IVW (multiplicative random effects)

0.86 (0.75–0.99)

0.039

0.135

MIP1a

Inflammatory disorders of breast

4

IVW

1.00 (0.76–1.30)

0.99

0.99

MIP1a

Inflammatory disorders of breast

4

IVW (multiplicative random effects)

1.00 (0.82–1.22)

0.986

0.99

MIP1b

Inflammatory disorders of breast

18

IVW

0.89 (0.76–1.04)

0.135

0.338

MIP1b

Inflammatory disorders of breast

18

IVW (multiplicative random effects)

0.89 (0.78–1.01)

0.072

0.338

RANTES/CCL5

Inflammatory disorders of breast

11

IVW

0.83 (0.71–0.98)

0.026

0.048

RANTES/CCL5

Inflammatory disorders of breast

11

IVW (multiplicative random effects)

0.83 (0.72–0.96)

0.011

0.048

SDF1a

Inflammatory disorders of breast

8

IVW

0.75 (0.55–1.01)

0.059

0.098

SDF1a

Inflammatory disorders of breast

8

IVW (multiplicative random effects)

0.75 (0.60–0.94)

0.012

0.058

Bngf

Inflammatory disorders of breast

6

IVW

0.92 (0.72–1.16)

0.478

0.478

Bngf

Inflammatory disorders of breast

6

IVW (multiplicative random effects)

0.92 (0.72–1.16)

0.478

0.478

FGFBasic

Inflammatory disorders of breast

7

IVW

0.99 (0.72–1.36)

0.951

0.951

FGFBasic

Inflammatory disorders of breast

7

IVW (multiplicative random effects)

0.99 (0.74–1.33)

0.948

0.951

GCSF

Inflammatory disorders of breast

9

IVW

0.84 (0.66–1.07)

0.16

0.2

GCSF

Inflammatory disorders of breast

9

IVW (multiplicative random effects)

0.84 (0.67–1.05)

0.129

0.2

HGF

Inflammatory disorders of breast

7

IVW

0.93 (0.68–1.28)

0.672

0.672

HGF

Inflammatory disorders of breast

7

IVW (multiplicative random effects)

0.93 (0.72–1.22)

0.614

0.672

MCSF

Inflammatory disorders of breast

9

IVW

0.94 (0.82–1.07)

0.325

0.666

MCSF

Inflammatory disorders of breast

9

IVW (multiplicative random effects)

0.94 (0.82–1.06)

0.307

0.666

PDGFbb

Inflammatory disorders of breast

12

IVW

0.91 (0.71–1.16)

0.435

0.706

PDGFbb

Inflammatory disorders of breast

12

IVW (multiplicative random effects)

0.91 (0.71–1.16)

0.435

0.706

SCF

Inflammatory disorders of breast

7

IVW

0.81 (0.57–1.14)

0.226

0.377

SCF

Inflammatory disorders of breast

7

IVW (multiplicative random effects)

0.81 (0.57–1.14)

0.226

0.377

SCGFb

Inflammatory disorders of breast

14

IVW

1.00 (0.86–1.15)

0.966

0.966

SCGFb

Inflammatory disorders of breast

14

IVW (multiplicative random effects)

1.00 (0.86–1.15)

0.966

0.966

VEGF

Inflammatory disorders of breast

8

IVW

1.20 (0.96–1.50)

0.106

0.264

VEGF

Inflammatory disorders of breast

8

IVW (multiplicative random effects)

1.20 (0.97–1.49)

0.095

0.264

IL-10

Inflammatory disorders of breast

8

IVW

1.17 (0.79–1.75)

0.432

0.719

IL-10

Inflammatory disorders of breast

8

IVW (multiplicative random effects)

1.17 (0.79–1.75)

0.432

0.719

IL-12p70

Inflammatory disorders of breast

3

IVW

1.04 (0.69–1.57)

0.858

0.962

IL-12p70

Inflammatory disorders of breast

3

IVW (multiplicative random effects)

1.04 (0.74–1.45)

0.824

0.962

IL-13

Inflammatory disorders of breast

10

IVW

1.03 (0.82–1.29)

0.831

0.831

IL-13(after outliers removal)

Inflammatory disorders of breast

8

IVW

0.90 (0.75–1.08)

0.247

0.617

IL-13

Inflammatory disorders of breast

10

IVW (multiplicative random effects)

1.03 (0.82–1.29)

0.831

0.831

IL-16

Inflammatory disorders of breast

9

IVW

1.03 (0.86–1.22)

0.762

0.974

IL-16

Inflammatory disorders of breast

9

IVW (multiplicative random effects)

1.03 (0.91–1.16)

0.676

0.974

IL-17

Inflammatory disorders of breast

11

IVW

0.97 (0.73–1.30)

0.863

0.863

IL-17

Inflammatory disorders of breast

11

IVW (multiplicative random effects)

0.97 (0.73–1.30)

0.863

0.863

IL-18

Inflammatory disorders of breast

13

IVW

1.07 (0.94–1.22)

0.288

0.719

IL-18

Inflammatory disorders of breast

13

IVW (multiplicative random effects)

1.07 (0.95–1.21)

0.269

0.719

IL-1b

Inflammatory disorders of breast

5

IVW

0.93 (0.71–1.21)

0.575

0.784

IL-1b

Inflammatory disorders of breast

5

IVW (multiplicative random effects)

0.93 (0.75–1.14)

0.474

0.784

IL-1ra

Inflammatory disorders of breast

7

IVW

0.92 (0.65–1.30)

0.633

0.633

IL-1ra (after outliers removal)

Inflammatory disorders of breast

6

IVW

0.78 (0.62–0.99)

0.038

0.095

IL-1ra

Inflammatory disorders of breast

7

IVW (multiplicative random effects)

0.92 (0.65–1.30)

0.633

0.633

IL-2

Inflammatory disorders of breast

8

IVW

0.94 (0.75–1.18)

0.603

0.854

IL-2

Inflammatory disorders of breast

8

IVW (multiplicative random effects)

0.94 (0.75–1.18)

0.603

0.854

IL-2ra

Inflammatory disorders of breast

6

IVW

1.22 (0.98–1.52)

0.075

0.125

IL-2ra

Inflammatory disorders of breast

6

IVW (multiplicative random effects)

1.22 (1.04–1.43)

0.014

0.07

IL-4

Inflammatory disorders of breast

9

IVW

1.12 (0.85–1.46)

0.424

0.557

IL-4

Inflammatory disorders of breast

9

IVW (multiplicative random effects)

1.12 (0.88–1.41)

0.363

0.557

IL-5

Inflammatory disorders of breast

4

IVW

1.00 (0.69–1.45)

0.999

0.999

IL-5

Inflammatory disorders of breast

4

IVW (multiplicative random effects)

1.00 (0.69–1.45)

0.999

0.999

IL-6

Inflammatory disorders of breast

4

IVW

0.81 (0.45–1.46)

0.487

0.812

IL-6

Inflammatory disorders of breast

4

IVW (multiplicative random effects)

0.81 (0.45–1.46)

0.487

0.812

IL-7

Inflammatory disorders of breast

8

IVW

0.87 (0.74–1.01)

0.075

0.188

IL-7

Inflammatory disorders of breast

8

IVW (multiplicative random effects)

0.87 (0.74–1.01)

0.075

0.188

IL-8

Inflammatory disorders of breast

3

IVW

0.97 (0.61–1.54)

0.9

0.9

IL-8

Inflammatory disorders of breast

3

IVW (multiplicative random effects)

0.97 (0.61–1.54)

0.9

0.9

IL-9

Inflammatory disorders of breast

6

IVW

0.87 (0.59–1.26)

0.453

0.566

IL-9 (after outliers removal)

Inflammatory disorders of breast

5

IVW

0.68 (0.52–0.89)

0.005

0.013

IL-9

Inflammatory disorders of breast

6

IVW (multiplicative random effects)

0.87 (0.59–1.26)

0.453

0.566

IFNg

Inflammatory disorders of breast

7

IVW

1.23 (0.90–1.68)

0.2

0.5

IFNg

Inflammatory disorders of breast

7

IVW (multiplicative random effects)

1.23 (0.95–1.58)

0.113

0.5

MIF

Inflammatory disorders of breast

9

IVW

0.94 (0.78–1.13)

0.503

0.503

MIF

Inflammatory disorders of breast

9

IVW (multiplicative random effects)

0.94 (0.80–1.11)

0.456

0.503

TNFa

Inflammatory disorders of breast

5

IVW

1.02 (0.81–1.29)

0.866

0.866

TNFa

Inflammatory disorders of breast

5

IVW (multiplicative random effects)

1.02 (0.89–1.17)

0.771

0.866

TNFb

Inflammatory disorders of breast

5

IVW

0.97 (0.80–1.17)

0.741

0.9

TNFb

Inflammatory disorders of breast

5

IVW (multiplicative random effects)

0.97 (0.80–1.17)

0.741

0.9

TRAIL

Inflammatory disorders of breast

17

IVW

0.93 (0.84–1.03)

0.162

0.295

TRAIL

Inflammatory disorders of breast

17

IVW (multiplicative random effects)

0.93 (0.86–1.01)

0.079

0.295