Table 1 Results of MR analysis of inflammatory factors and inflammatory disorders of the breast by inverse variance weighted method.
Exposure | Outcome | N.SNP | Method | OR (95% CI) | P | FDR adjusted P |
---|---|---|---|---|---|---|
CTACK/CCL27 | Inflammatory disorders of breast | 9 | IVW | 1.01 (0.83–1.24) | 0.904 | 0.94 |
CTACK/CCL27 | Inflammatory disorders of breast | 9 | IVW (multiplicative random effects) | 1.01 (0.83–1.24) | 0.904 | 0.94 |
Eotaxin | Inflammatory disorders of breast | 13 | IVW | 0.98 (0.78–1.24) | 0.892 | 0.892 |
Eotaxin | Inflammatory disorders of breast | 13 | IVW (multiplicative random effects) | 0.98 (0.78–1.24) | 0.892 | 0.892 |
GROa | Inflammatory disorders of breast | 7 | IVW | 0.86 (0.74–0.99) | 0.04 | 0.099 |
GROa | Inflammatory disorders of breast | 7 | IVW (multiplicative random effects) | 0.86 (0.75–0.98) | 0.026 | 0.099 |
MCP1 | Inflammatory disorders of breast | 5 | IVW | 0.88 (0.63–1.23) | 0.458 | 0.938 |
MCP1 | Inflammatory disorders of breast | 5 | IVW (multiplicative random effects) | 0.88 (0.63–1.23) | 0.458 | 0.938 |
MCP3 | Inflammatory disorders of breast | 2 | IVW | 0.91 (0.72–1.14) | 0.408 | 0.408 |
MCP3 | Inflammatory disorders of breast | 2 | IVW (multiplicative random effects) | 0.91 (0.83–0.99) | 0.033 | 0.067 |
MIG | Inflammatory disorders of breast | 13 | IVW | 0.86 (0.74–1.00) | 0.054 | 0.135 |
MIG | Inflammatory disorders of breast | 13 | IVW (multiplicative random effects) | 0.86 (0.75–0.99) | 0.039 | 0.135 |
MIP1a | Inflammatory disorders of breast | 4 | IVW | 1.00 (0.76–1.30) | 0.99 | 0.99 |
MIP1a | Inflammatory disorders of breast | 4 | IVW (multiplicative random effects) | 1.00 (0.82–1.22) | 0.986 | 0.99 |
MIP1b | Inflammatory disorders of breast | 18 | IVW | 0.89 (0.76–1.04) | 0.135 | 0.338 |
MIP1b | Inflammatory disorders of breast | 18 | IVW (multiplicative random effects) | 0.89 (0.78–1.01) | 0.072 | 0.338 |
RANTES/CCL5 | Inflammatory disorders of breast | 11 | IVW | 0.83 (0.71–0.98) | 0.026 | 0.048 |
RANTES/CCL5 | Inflammatory disorders of breast | 11 | IVW (multiplicative random effects) | 0.83 (0.72–0.96) | 0.011 | 0.048 |
SDF1a | Inflammatory disorders of breast | 8 | IVW | 0.75 (0.55–1.01) | 0.059 | 0.098 |
SDF1a | Inflammatory disorders of breast | 8 | IVW (multiplicative random effects) | 0.75 (0.60–0.94) | 0.012 | 0.058 |
Bngf | Inflammatory disorders of breast | 6 | IVW | 0.92 (0.72–1.16) | 0.478 | 0.478 |
Bngf | Inflammatory disorders of breast | 6 | IVW (multiplicative random effects) | 0.92 (0.72–1.16) | 0.478 | 0.478 |
FGFBasic | Inflammatory disorders of breast | 7 | IVW | 0.99 (0.72–1.36) | 0.951 | 0.951 |
FGFBasic | Inflammatory disorders of breast | 7 | IVW (multiplicative random effects) | 0.99 (0.74–1.33) | 0.948 | 0.951 |
GCSF | Inflammatory disorders of breast | 9 | IVW | 0.84 (0.66–1.07) | 0.16 | 0.2 |
GCSF | Inflammatory disorders of breast | 9 | IVW (multiplicative random effects) | 0.84 (0.67–1.05) | 0.129 | 0.2 |
HGF | Inflammatory disorders of breast | 7 | IVW | 0.93 (0.68–1.28) | 0.672 | 0.672 |
HGF | Inflammatory disorders of breast | 7 | IVW (multiplicative random effects) | 0.93 (0.72–1.22) | 0.614 | 0.672 |
MCSF | Inflammatory disorders of breast | 9 | IVW | 0.94 (0.82–1.07) | 0.325 | 0.666 |
MCSF | Inflammatory disorders of breast | 9 | IVW (multiplicative random effects) | 0.94 (0.82–1.06) | 0.307 | 0.666 |
PDGFbb | Inflammatory disorders of breast | 12 | IVW | 0.91 (0.71–1.16) | 0.435 | 0.706 |
PDGFbb | Inflammatory disorders of breast | 12 | IVW (multiplicative random effects) | 0.91 (0.71–1.16) | 0.435 | 0.706 |
SCF | Inflammatory disorders of breast | 7 | IVW | 0.81 (0.57–1.14) | 0.226 | 0.377 |
SCF | Inflammatory disorders of breast | 7 | IVW (multiplicative random effects) | 0.81 (0.57–1.14) | 0.226 | 0.377 |
SCGFb | Inflammatory disorders of breast | 14 | IVW | 1.00 (0.86–1.15) | 0.966 | 0.966 |
SCGFb | Inflammatory disorders of breast | 14 | IVW (multiplicative random effects) | 1.00 (0.86–1.15) | 0.966 | 0.966 |
VEGF | Inflammatory disorders of breast | 8 | IVW | 1.20 (0.96–1.50) | 0.106 | 0.264 |
VEGF | Inflammatory disorders of breast | 8 | IVW (multiplicative random effects) | 1.20 (0.97–1.49) | 0.095 | 0.264 |
IL-10 | Inflammatory disorders of breast | 8 | IVW | 1.17 (0.79–1.75) | 0.432 | 0.719 |
IL-10 | Inflammatory disorders of breast | 8 | IVW (multiplicative random effects) | 1.17 (0.79–1.75) | 0.432 | 0.719 |
IL-12p70 | Inflammatory disorders of breast | 3 | IVW | 1.04 (0.69–1.57) | 0.858 | 0.962 |
IL-12p70 | Inflammatory disorders of breast | 3 | IVW (multiplicative random effects) | 1.04 (0.74–1.45) | 0.824 | 0.962 |
IL-13 | Inflammatory disorders of breast | 10 | IVW | 1.03 (0.82–1.29) | 0.831 | 0.831 |
IL-13(after outliers removal) | Inflammatory disorders of breast | 8 | IVW | 0.90 (0.75–1.08) | 0.247 | 0.617 |
IL-13 | Inflammatory disorders of breast | 10 | IVW (multiplicative random effects) | 1.03 (0.82–1.29) | 0.831 | 0.831 |
IL-16 | Inflammatory disorders of breast | 9 | IVW | 1.03 (0.86–1.22) | 0.762 | 0.974 |
IL-16 | Inflammatory disorders of breast | 9 | IVW (multiplicative random effects) | 1.03 (0.91–1.16) | 0.676 | 0.974 |
IL-17 | Inflammatory disorders of breast | 11 | IVW | 0.97 (0.73–1.30) | 0.863 | 0.863 |
IL-17 | Inflammatory disorders of breast | 11 | IVW (multiplicative random effects) | 0.97 (0.73–1.30) | 0.863 | 0.863 |
IL-18 | Inflammatory disorders of breast | 13 | IVW | 1.07 (0.94–1.22) | 0.288 | 0.719 |
IL-18 | Inflammatory disorders of breast | 13 | IVW (multiplicative random effects) | 1.07 (0.95–1.21) | 0.269 | 0.719 |
IL-1b | Inflammatory disorders of breast | 5 | IVW | 0.93 (0.71–1.21) | 0.575 | 0.784 |
IL-1b | Inflammatory disorders of breast | 5 | IVW (multiplicative random effects) | 0.93 (0.75–1.14) | 0.474 | 0.784 |
IL-1ra | Inflammatory disorders of breast | 7 | IVW | 0.92 (0.65–1.30) | 0.633 | 0.633 |
IL-1ra (after outliers removal) | Inflammatory disorders of breast | 6 | IVW | 0.78 (0.62–0.99) | 0.038 | 0.095 |
IL-1ra | Inflammatory disorders of breast | 7 | IVW (multiplicative random effects) | 0.92 (0.65–1.30) | 0.633 | 0.633 |
IL-2 | Inflammatory disorders of breast | 8 | IVW | 0.94 (0.75–1.18) | 0.603 | 0.854 |
IL-2 | Inflammatory disorders of breast | 8 | IVW (multiplicative random effects) | 0.94 (0.75–1.18) | 0.603 | 0.854 |
IL-2ra | Inflammatory disorders of breast | 6 | IVW | 1.22 (0.98–1.52) | 0.075 | 0.125 |
IL-2ra | Inflammatory disorders of breast | 6 | IVW (multiplicative random effects) | 1.22 (1.04–1.43) | 0.014 | 0.07 |
IL-4 | Inflammatory disorders of breast | 9 | IVW | 1.12 (0.85–1.46) | 0.424 | 0.557 |
IL-4 | Inflammatory disorders of breast | 9 | IVW (multiplicative random effects) | 1.12 (0.88–1.41) | 0.363 | 0.557 |
IL-5 | Inflammatory disorders of breast | 4 | IVW | 1.00 (0.69–1.45) | 0.999 | 0.999 |
IL-5 | Inflammatory disorders of breast | 4 | IVW (multiplicative random effects) | 1.00 (0.69–1.45) | 0.999 | 0.999 |
IL-6 | Inflammatory disorders of breast | 4 | IVW | 0.81 (0.45–1.46) | 0.487 | 0.812 |
IL-6 | Inflammatory disorders of breast | 4 | IVW (multiplicative random effects) | 0.81 (0.45–1.46) | 0.487 | 0.812 |
IL-7 | Inflammatory disorders of breast | 8 | IVW | 0.87 (0.74–1.01) | 0.075 | 0.188 |
IL-7 | Inflammatory disorders of breast | 8 | IVW (multiplicative random effects) | 0.87 (0.74–1.01) | 0.075 | 0.188 |
IL-8 | Inflammatory disorders of breast | 3 | IVW | 0.97 (0.61–1.54) | 0.9 | 0.9 |
IL-8 | Inflammatory disorders of breast | 3 | IVW (multiplicative random effects) | 0.97 (0.61–1.54) | 0.9 | 0.9 |
IL-9 | Inflammatory disorders of breast | 6 | IVW | 0.87 (0.59–1.26) | 0.453 | 0.566 |
IL-9 (after outliers removal) | Inflammatory disorders of breast | 5 | IVW | 0.68 (0.52–0.89) | 0.005 | 0.013 |
IL-9 | Inflammatory disorders of breast | 6 | IVW (multiplicative random effects) | 0.87 (0.59–1.26) | 0.453 | 0.566 |
IFNg | Inflammatory disorders of breast | 7 | IVW | 1.23 (0.90–1.68) | 0.2 | 0.5 |
IFNg | Inflammatory disorders of breast | 7 | IVW (multiplicative random effects) | 1.23 (0.95–1.58) | 0.113 | 0.5 |
MIF | Inflammatory disorders of breast | 9 | IVW | 0.94 (0.78–1.13) | 0.503 | 0.503 |
MIF | Inflammatory disorders of breast | 9 | IVW (multiplicative random effects) | 0.94 (0.80–1.11) | 0.456 | 0.503 |
TNFa | Inflammatory disorders of breast | 5 | IVW | 1.02 (0.81–1.29) | 0.866 | 0.866 |
TNFa | Inflammatory disorders of breast | 5 | IVW (multiplicative random effects) | 1.02 (0.89–1.17) | 0.771 | 0.866 |
TNFb | Inflammatory disorders of breast | 5 | IVW | 0.97 (0.80–1.17) | 0.741 | 0.9 |
TNFb | Inflammatory disorders of breast | 5 | IVW (multiplicative random effects) | 0.97 (0.80–1.17) | 0.741 | 0.9 |
TRAIL | Inflammatory disorders of breast | 17 | IVW | 0.93 (0.84–1.03) | 0.162 | 0.295 |
TRAIL | Inflammatory disorders of breast | 17 | IVW (multiplicative random effects) | 0.93 (0.86–1.01) | 0.079 | 0.295 |