Table 4 MR-Steiger analysis of the causal directions between inflammatory factors and inflammatory disorders of the breast.
Exposure | Outcome | snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval | FDR adjusted P |
---|---|---|---|---|---|---|
CTACK/CCL27 | Inflammatory disorders of breast | 0.064648 | 4.94E-05 | TRUE | 1.45E-51 | 4.58E-51 |
Bngf | Inflammatory disorders of breast | 0.041725 | 3.04E-05 | TRUE | 1.49E-32 | 1.97E-32 |
VEGF | Inflammatory disorders of breast | 0.039879 | 4.30E-05 | TRUE | 2.16E-59 | 8.85E-59 |
MIF | Inflammatory disorders of breast | 0.065745 | 3.23E-05 | TRUE | 4.19E-51 | 1.23E-50 |
TRAIL | Inflammatory disorders of breast | 0.177862 | 5.68E-05 | TRUE | 0 | 0 |
TNFb | Inflammatory disorders of breast | 0.112971 | 3.25E-05 | TRUE | 1.19E-41 | 2.21E-41 |
TNFa | Inflammatory disorders of breast | 0.033457 | 6.43E-06 | TRUE | 2.09E-26 | 2.60E-26 |
SDF1a | Inflammatory disorders of breast | 0.030073 | 3.51E-05 | TRUE | 3.23E-38 | 5.75E-38 |
SCGFb | Inflammatory disorders of breast | 0.128598 | 8.57E-05 | TRUE | 2.18E-107 | 2.98E-106 |
SCF | Inflammatory disorders of breast | 0.019604 | 4.42E-05 | TRUE | 3.79E-33 | 5.35E-33 |
IL-16 | Inflammatory disorders of breast | 0.064373 | 2.00E-05 | TRUE | 2.58E-50 | 6.61E-50 |
RANTES/CCL5 | Inflammatory disorders of breast | 0.077154 | 5.89E-05 | TRUE | 2.54E-58 | 9.46E-58 |
PDGFbb | Inflammatory disorders of breast | 0.045289 | 7.29E-05 | TRUE | 9.24E-77 | 7.58E-76 |
MIP1b | Inflammatory disorders of breast | 0.081181 | 6.53E-05 | TRUE | 4.08E-142 | 8.37E-141 |
MIP1a | Inflammatory disorders of breast | 0.025427 | 8.06E-06 | TRUE | 1.46E-20 | 1.57E-20 |
MIG | Inflammatory disorders of breast | 0.080421 | 6.63E-05 | TRUE | 3.36E-65 | 1.72E-64 |
MCSF | Inflammatory disorders of breast | 0.248776 | 3.93E-05 | TRUE | 4.35E-55 | 1.49E-54 |
MCP3 | Inflammatory disorders of breast | 0.051587 | 3.91E-06 | TRUE | 3.37E-11 | 3.46E-11 |
MCP1 | Inflammatory disorders of breast | 0.026356 | 3.55E-05 | TRUE | 3.79E-45 | 7.77E-45 |
IL-12p70 | Inflammatory disorders of breast | 0.011524 | 6.21E-06 | TRUE | 5.91E-21 | 6.55E-21 |
IP10 | Inflammatory disorders of breast | 0.006476 | 1.09E-06 | TRUE | 1.68E-06 | 1.68E-06 |
IL-18 | Inflammatory disorders of breast | 0.125189 | 6.19E-05 | TRUE | 8.95E-104 | 9.17E-103 |
IL-17 | Inflammatory disorders of breast | 0.032474 | 8.40E-05 | TRUE | 1.15E-50 | 3.15E-50 |
IL-13 | Inflammatory disorders of breast | 0.063647 | 7.62E-05 | TRUE | 4.18E-49 | 1.01E-48 |
IL-10 | Inflammatory disorders of breast | 0.024428 | 7.34E-05 | TRUE | 1.13E-37 | 1.92E-37 |
IL-8 | Inflammatory disorders of breast | 0.019847 | 1.90E-05 | TRUE | 5.85E-16 | 6.15E-16 |
IL-6 | Inflammatory disorders of breast | 0.013603 | 3.15E-05 | TRUE | 3.97E-23 | 4.52E-23 |
IL-1ra | Inflammatory disorders of breast | 0.043379 | 7.74E-05 | TRUE | 9.26E-34 | 1.41E-33 |
IL-1b | Inflammatory disorders of breast | 0.033195 | 1.30E-05 | TRUE | 6.51E-25 | 7.63E-25 |
HGF | Inflammatory disorders of breast | 0.019265 | 2.07E-05 | TRUE | 1.47E-33 | 2.15E-33 |
IL-9 | Inflammatory disorders of breast | 0.036695 | 7.21E-05 | TRUE | 1.53E-28 | 1.97E-28 |
IL-7 | Inflammatory disorders of breast | 0.096206 | 6.03E-05 | TRUE | 2.17E-73 | 1.48E-72 |
IL-5 | Inflammatory disorders of breast | 0.034051 | 2.95E-05 | TRUE | 1.90E-25 | 2.29E-25 |
IL-4 | Inflammatory disorders of breast | 0.028806 | 4.05E-05 | TRUE | 2.98E-48 | 6.80E-48 |
IL-2ra | Inflammatory disorders of breast | 0.042557 | 4.16E-05 | TRUE | 3.48E-34 | 5.48E-34 |
IL-2 | Inflammatory disorders of breast | 0.057603 | 7.95E-05 | TRUE | 3.08E-43 | 6.01E-43 |
IFNg | Inflammatory disorders of breast | 0.02136 | 2.60E-05 | TRUE | 1.70E-34 | 2.78E-34 |
GROa | Inflammatory disorders of breast | 0.090317 | 4.37E-05 | TRUE | 5.45E-71 | 3.19E-70 |
GCSF | Inflammatory disorders of breast | 0.029391 | 5.07E-05 | TRUE | 1.37E-47 | 2.95E-47 |
FGFBasic | Inflammatory disorders of breast | 0.020782 | 2.49E-05 | TRUE | 4.53E-33 | 6.19E-33 |