Table 4 MR-Steiger analysis of the causal directions between inflammatory factors and inflammatory disorders of the breast.

From: Genetic determinants of inflammatory cytokines and their causal relationship with inflammatory disorders of breast: a two-sample Mendelian randomization study

Exposure

Outcome

snp_r2.exposure

snp_r2.outcome

correct_causal_direction

steiger_pval

FDR adjusted P

CTACK/CCL27

Inflammatory disorders of breast

0.064648

4.94E-05

TRUE

1.45E-51

4.58E-51

Bngf

Inflammatory disorders of breast

0.041725

3.04E-05

TRUE

1.49E-32

1.97E-32

VEGF

Inflammatory disorders of breast

0.039879

4.30E-05

TRUE

2.16E-59

8.85E-59

MIF

Inflammatory disorders of breast

0.065745

3.23E-05

TRUE

4.19E-51

1.23E-50

TRAIL

Inflammatory disorders of breast

0.177862

5.68E-05

TRUE

0

0

TNFb

Inflammatory disorders of breast

0.112971

3.25E-05

TRUE

1.19E-41

2.21E-41

TNFa

Inflammatory disorders of breast

0.033457

6.43E-06

TRUE

2.09E-26

2.60E-26

SDF1a

Inflammatory disorders of breast

0.030073

3.51E-05

TRUE

3.23E-38

5.75E-38

SCGFb

Inflammatory disorders of breast

0.128598

8.57E-05

TRUE

2.18E-107

2.98E-106

SCF

Inflammatory disorders of breast

0.019604

4.42E-05

TRUE

3.79E-33

5.35E-33

IL-16

Inflammatory disorders of breast

0.064373

2.00E-05

TRUE

2.58E-50

6.61E-50

RANTES/CCL5

Inflammatory disorders of breast

0.077154

5.89E-05

TRUE

2.54E-58

9.46E-58

PDGFbb

Inflammatory disorders of breast

0.045289

7.29E-05

TRUE

9.24E-77

7.58E-76

MIP1b

Inflammatory disorders of breast

0.081181

6.53E-05

TRUE

4.08E-142

8.37E-141

MIP1a

Inflammatory disorders of breast

0.025427

8.06E-06

TRUE

1.46E-20

1.57E-20

MIG

Inflammatory disorders of breast

0.080421

6.63E-05

TRUE

3.36E-65

1.72E-64

MCSF

Inflammatory disorders of breast

0.248776

3.93E-05

TRUE

4.35E-55

1.49E-54

MCP3

Inflammatory disorders of breast

0.051587

3.91E-06

TRUE

3.37E-11

3.46E-11

MCP1

Inflammatory disorders of breast

0.026356

3.55E-05

TRUE

3.79E-45

7.77E-45

IL-12p70

Inflammatory disorders of breast

0.011524

6.21E-06

TRUE

5.91E-21

6.55E-21

IP10

Inflammatory disorders of breast

0.006476

1.09E-06

TRUE

1.68E-06

1.68E-06

IL-18

Inflammatory disorders of breast

0.125189

6.19E-05

TRUE

8.95E-104

9.17E-103

IL-17

Inflammatory disorders of breast

0.032474

8.40E-05

TRUE

1.15E-50

3.15E-50

IL-13

Inflammatory disorders of breast

0.063647

7.62E-05

TRUE

4.18E-49

1.01E-48

IL-10

Inflammatory disorders of breast

0.024428

7.34E-05

TRUE

1.13E-37

1.92E-37

IL-8

Inflammatory disorders of breast

0.019847

1.90E-05

TRUE

5.85E-16

6.15E-16

IL-6

Inflammatory disorders of breast

0.013603

3.15E-05

TRUE

3.97E-23

4.52E-23

IL-1ra

Inflammatory disorders of breast

0.043379

7.74E-05

TRUE

9.26E-34

1.41E-33

IL-1b

Inflammatory disorders of breast

0.033195

1.30E-05

TRUE

6.51E-25

7.63E-25

HGF

Inflammatory disorders of breast

0.019265

2.07E-05

TRUE

1.47E-33

2.15E-33

IL-9

Inflammatory disorders of breast

0.036695

7.21E-05

TRUE

1.53E-28

1.97E-28

IL-7

Inflammatory disorders of breast

0.096206

6.03E-05

TRUE

2.17E-73

1.48E-72

IL-5

Inflammatory disorders of breast

0.034051

2.95E-05

TRUE

1.90E-25

2.29E-25

IL-4

Inflammatory disorders of breast

0.028806

4.05E-05

TRUE

2.98E-48

6.80E-48

IL-2ra

Inflammatory disorders of breast

0.042557

4.16E-05

TRUE

3.48E-34

5.48E-34

IL-2

Inflammatory disorders of breast

0.057603

7.95E-05

TRUE

3.08E-43

6.01E-43

IFNg

Inflammatory disorders of breast

0.02136

2.60E-05

TRUE

1.70E-34

2.78E-34

GROa

Inflammatory disorders of breast

0.090317

4.37E-05

TRUE

5.45E-71

3.19E-70

GCSF

Inflammatory disorders of breast

0.029391

5.07E-05

TRUE

1.37E-47

2.95E-47

FGFBasic

Inflammatory disorders of breast

0.020782

2.49E-05

TRUE

4.53E-33

6.19E-33