Fig. 3
From: Streptozotocin-induced hyperglycemia unmasks cardiotoxicity induced by doxorubicin
Effect of streptozotocin-induced hyperglycemia and doxorubicin on cardiomyocytes atrophy and capillary rarefaction. (A) Double immunostaining of vinculin (green) and caveolin-1 (red) proteins on cardiac sections of saline (Ctl), doxorubicin (Dox), streptozotocin (STZ) and both doxorubicin and diabetes (Dox-STZ) treated mice. Histograms indicate the cross-sectional area of myocytes (B) and the capillary/cardiomyocyte ratio (D) measured in the 4 groups. (C,E) protein expression of MuRF-1 and VEGF-A, respectively, measured in the cardiac tissue par western blot. *p < 0.05, **p < 0.01 and ***p < 0.001 compared to the “Ctl” condition or otherwise specified. Scale, 100 µm.
