Fig. 2 | Scientific Reports

Fig. 2

From: Circulating biomarkers and neuroanatomical brain structures differ in older adults with and without post-traumatic stress disorder

Fig. 2

PTSD and non-PTSD cohorts by BDNF Val66Met (rs6265) polymorphism. (a) Genotype distribution by PTSD diagnosis (Fisher-Freeman-Halton Exact test = 7.284, p = 0.015). Violin plots of plasma and serum levels of (b) BDNF (xMAP), (c) Mature BDNF (ELISA) and (d) ProBDNF (ELISA) by both PTSD diagnosis and genotype. Overall group differences were determined using the Kruskal-Wallis H test. Pairwise differences, when significant after Bonferroni correction for multiple tests, are indicated within the graphs by a bar and p-value. Coloured circles represent individual sample concentrations; Unfilled circles represent samples below the assay detection limit which were assigned values of half the lower limit of quantification (LLOQ) for analysis; Solid faded circles represent samples with concentrations estimated from the analysis software (detectable but below the LLOQ); Line represents the sample set mean; White square represents the sample set median; NS = not significant (p > 0.05), *indicates p values still significant after Bonferroni multi-comparison correction (p ≤ 0.013).

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